Nancy G Kutner1, Rebecca Zhang, Yijian Huang, Donald L Bliwise. 1. Rehabilitation/Quality of Life Special Studies Center, United States Renal Data System, Emory University, CRM-1441 Clifton Rd. NE, Atlanta, GA 30322, USA. nkutner@emory.edu
Abstract
BACKGROUND: Research in the general population indicates that sleep fragmentation is detrimental for cognitive function, but little attention has been given to this issue in dialysis patients. We hypothesized that patients with self-reported persistent sleep difficulty would have an increased risk of scoring lower on a cognitive function measure at follow-up compared to their score at baseline. METHODS: Sleep difficulty and cognitive function were reported by a large national patient cohort near the start of dialysis and at a 9- to 12-month follow-up. Logistic regression was used to investigate the risk of scoring lower on a cognitive function measure at follow-up as a function of self-reported sleep difficulty, controlling for patients' sociodemographic, clinical and treatment characteristics, including depressed mood. RESULTS: At follow-up, cognitive function scores were lower among 35.8% of the cohort. Patients with self-reported persistent sleep difficulty had the lowest average cognitive function score. Men with reported persistent sleep difficulty, regardless of presence of depressed mood, had a significantly increased risk of a lower cognitive function score at follow-up. Women with reported persistent sleep difficulty as well as depressed mood had significantly increased risk of a lower cognitive function score. CONCLUSION: The potential impact of sleep difficulty and depressed mood on the cognitive function of dialysis patients emphasizes the importance of evaluating and treating these risks and highlights the value of continued research to improve our understanding and management of these issues.
BACKGROUND: Research in the general population indicates that sleep fragmentation is detrimental for cognitive function, but little attention has been given to this issue in dialysis patients. We hypothesized that patients with self-reported persistent sleep difficulty would have an increased risk of scoring lower on a cognitive function measure at follow-up compared to their score at baseline. METHODS: Sleep difficulty and cognitive function were reported by a large national patient cohort near the start of dialysis and at a 9- to 12-month follow-up. Logistic regression was used to investigate the risk of scoring lower on a cognitive function measure at follow-up as a function of self-reported sleep difficulty, controlling for patients' sociodemographic, clinical and treatment characteristics, including depressed mood. RESULTS: At follow-up, cognitive function scores were lower among 35.8% of the cohort. Patients with self-reported persistent sleep difficulty had the lowest average cognitive function score. Men with reported persistent sleep difficulty, regardless of presence of depressed mood, had a significantly increased risk of a lower cognitive function score at follow-up. Women with reported persistent sleep difficulty as well as depressed mood had significantly increased risk of a lower cognitive function score. CONCLUSION: The potential impact of sleep difficulty and depressed mood on the cognitive function of dialysis patients emphasizes the importance of evaluating and treating these risks and highlights the value of continued research to improve our understanding and management of these issues.
Authors: M Thomas; H Sing; G Belenky; H Holcomb; H Mayberg; R Dannals; H Wagner; D Thorne; K Popp; L Rowland; A Welsh; S Balwinski; D Redmond Journal: J Sleep Res Date: 2000-12 Impact factor: 3.981
Authors: Huseyin Atalay; Yalcin Solak; Murat Biyik; Zeynep Biyik; Mehdi Yeksan; Faruk Uguz; Ibrahim Guney; Halil Zeki Tonbul; Suleyman Turk Journal: Int Urol Nephrol Date: 2009-12-02 Impact factor: 2.370
Authors: Mark L Unruh; Mark H Sanders; Susan Redline; Beth M Piraino; Jason G Umans; Hassan Chami; Rohit Budhiraja; Naresh M Punjabi; Daniel Buysse; Anne B Newman Journal: Am J Kidney Dis Date: 2008-07-09 Impact factor: 8.860
Authors: Dnyelle Souza Silva; Elisangela dos Santos Prado Andrade; Rosilene Motta Elias; Elias David-Neto; William Carlos Nahas; Manuel Carlos Martins de Castro; Maria Cristina Ribeiro de Castro Journal: Clinics (Sao Paulo) Date: 2012-12 Impact factor: 2.365