Teresa Rodrigues1, Henrique Barros. 1. Department of Hygiene and Epidemiology, University of Porto Medical School, Al. Prof. Hernani Monteiro, 4200-319 Porto, Portugal. tererod@med.up.pt
Abstract
OBJECTIVE: To identify risk factors for small-for-gestational-age and preterm in a Portuguese cohort of newborns. STUDY DESIGN: Socio-demographic, anthropometric, behavioural and obstetrical characteristics were evaluated in 4.193 women consecutively delivered. Term small-for-gestational-age (n = 342) and non-small-for-gestational-age preterm (n = 148) were compared to non-small-for-gestational-age term births (n = 3538). Adjusted odds ratios and etiologic fractions were calculated. RESULTS: Low height, low weight when entering pregnancy and low weight gain were significantly associated with small-for-gestational-age, but not preterm. These were the factors with the highest etiologic fraction for small-for-gestational-age. An increased risk of small-for-gestational-age was found for women who smoked during pregnancy (OR = 2.39; 95% CI: 1.66-3.46) and began antenatal care after pregnancy first trimester (OR = 1.86; 95% CI: 1.32-2.62). Previous abortion was associated with small-for-gestational-age (OR = 1.72; 95% CI: 1.16-2.55) and previous preterm with preterm (OR = 3.20; 95% CI: 1.26-8.14). CONCLUSIONS: Low anthropometrics, smoking and late antenatal care were risk factors for small-for-gestational-age, but not preterm. Maternal anthropometrics were the factors with the highest impact on small-for-gestational-age. No factor showed a great contribution to preterm birth.
OBJECTIVE: To identify risk factors for small-for-gestational-age and preterm in a Portuguese cohort of newborns. STUDY DESIGN: Socio-demographic, anthropometric, behavioural and obstetrical characteristics were evaluated in 4.193 women consecutively delivered. Term small-for-gestational-age (n = 342) and non-small-for-gestational-age preterm (n = 148) were compared to non-small-for-gestational-age term births (n = 3538). Adjusted odds ratios and etiologic fractions were calculated. RESULTS: Low height, low weight when entering pregnancy and low weight gain were significantly associated with small-for-gestational-age, but not preterm. These were the factors with the highest etiologic fraction for small-for-gestational-age. An increased risk of small-for-gestational-age was found for women who smoked during pregnancy (OR = 2.39; 95% CI: 1.66-3.46) and began antenatal care after pregnancy first trimester (OR = 1.86; 95% CI: 1.32-2.62). Previous abortion was associated with small-for-gestational-age (OR = 1.72; 95% CI: 1.16-2.55) and previous preterm with preterm (OR = 3.20; 95% CI: 1.26-8.14). CONCLUSIONS: Low anthropometrics, smoking and late antenatal care were risk factors for small-for-gestational-age, but not preterm. Maternal anthropometrics were the factors with the highest impact on small-for-gestational-age. No factor showed a great contribution to preterm birth.
Authors: David M Ferrero; Jim Larson; Bo Jacobsson; Gian Carlo Di Renzo; Jane E Norman; James N Martin; Mary D'Alton; Ernesto Castelazo; Chris P Howson; Verena Sengpiel; Matteo Bottai; Jonathan A Mayo; Gary M Shaw; Ivan Verdenik; Nataša Tul; Petr Velebil; Sarah Cairns-Smith; Hamid Rushwan; Sabaratnam Arulkumaran; Jennifer L Howse; Joe Leigh Simpson Journal: PLoS One Date: 2016-09-13 Impact factor: 3.240