BACKGROUND: Previous investigations have revealed an association of androgenetic alopecia (AGA), especially in younger subjects with severe early-onset AGA, with ischemic heart disease. OBJECTIVE: To examine the possible association between early-onset alopecia and low-grade inflammation measured by high-sensitivity C-reactive protein (hs-CRP) that has been recommended for the assessment of the cardiovascular disease (CVD) risk. METHODS: The study population consisted of young men (n = 727, aged 25-34 years) participating in a national survey. The grade of alopecia was assessed by a trained nurse using the Norwood/Hamilton Classification Scale. RESULTS: Men with moderate to extensive alopecia (17%) had a higher body mass index and larger waist, upper arm, hip and waist circumference than those with little to no alopecia (p < 0.05), and statistically insignificant differences were seen in the waist-to-hip circumference ratio (WHR), diastolic blood pressure and hs-CRP. With increasing hs-CRP, the mean WHR increased, but only among men with moderate to extensive alopecia (p = 0.043). CONCLUSION: Our findings show a relation between moderate to extensive alopecia and low-grade inflammation--a predictor of a future CVD--especially combined with central obesity, among men younger than 35 years. Copyright 2007 S. Karger AG, Basel.
BACKGROUND: Previous investigations have revealed an association of androgenetic alopecia (AGA), especially in younger subjects with severe early-onset AGA, with ischemic heart disease. OBJECTIVE: To examine the possible association between early-onset alopecia and low-grade inflammation measured by high-sensitivity C-reactive protein (hs-CRP) that has been recommended for the assessment of the cardiovascular disease (CVD) risk. METHODS: The study population consisted of young men (n = 727, aged 25-34 years) participating in a national survey. The grade of alopecia was assessed by a trained nurse using the Norwood/Hamilton Classification Scale. RESULTS:Men with moderate to extensive alopecia (17%) had a higher body mass index and larger waist, upper arm, hip and waist circumference than those with little to no alopecia (p < 0.05), and statistically insignificant differences were seen in the waist-to-hip circumference ratio (WHR), diastolic blood pressure and hs-CRP. With increasing hs-CRP, the mean WHR increased, but only among men with moderate to extensive alopecia (p = 0.043). CONCLUSION: Our findings show a relation between moderate to extensive alopecia and low-grade inflammation--a predictor of a future CVD--especially combined with central obesity, among men younger than 35 years. Copyright 2007 S. Karger AG, Basel.
Authors: Axel M Hillmer; Antonia Flaquer; Sandra Hanneken; Sibylle Eigelshoven; Anne-Katrin Kortüm; Felix F Brockschmidt; Astrid Golla; Christine Metzen; Holger Thiele; Susanne Kolberg; Roman Reinartz; Regina C Betz; Thomas Ruzicka; Hans Christian Hennies; Roland Kruse; Markus M Nöthen Journal: Am J Hum Genet Date: 2008-02-21 Impact factor: 11.025
Authors: I Sari; K Aykent; V Davutoglu; M Yuce; O Ozer; M Kaplan; H Alici; S Ercan; M Sunbul; K Tigen Journal: Neth Heart J Date: 2015-04-01 Impact factor: 2.380