Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model.

Literature DB >> 17341841

Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model.

Takahiro Matsuya¹, Kazuhiro Takuma, Kosuke Sato, Makoto Asai, Yoshihiro Murakami, Sosuke Miyoshi, Akihiro Noda, Taku Nagai, Hiroyuki Mizoguchi, Shintaro Nishimura, Kiyofumi Yamada.

Abstract

In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A(2A) antagonist SCH-58261, but not the A(1)-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine or A(2B)-receptor antagonist alloxazine, synergistically potentiated the L-DOPA-induced rotational behaviors in the 6-OHDA-lesioned mice. In addtion, the 6-OHDA-induced lesions of the dopaminergic system did not affect the in vivo binding of an adenosine A(2A)-receptor tracer [(11)C]SCH-442416 in the striatatum. These findings suggest that adenosine A(2A) antagonists are extremely useful for pharmacotherapy of L-DOPA in Parkinson's disease patients.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17341841 DOI： 10.1254/jphs.scz070058

Source DB: PubMed Journal: J Pharmacol Sci ISSN： 1347-8613 Impact factor: 3.337

Keyword Cloud
Cited

8 in total

1. The effects of systemic, intrastriatal, and intrapallidal injections of caffeine and systemic injections of A2A and A1 antagonists on forepaw stepping in the unilateral 6-OHDA-lesioned rat.

Authors: John E Kelsey; Nicole A Langelier; Brad S Oriel; Catherine Reedy
Journal: Psychopharmacology (Berl) Date: 2008-09-13 Impact factor: 4.530

2. Dopamine D₂ and Adenosine A_2A Receptors Interaction on Ca²⁺ Current Modulation in a Rodent Model of Parkinsonism.

Authors: Ernesto Alberto Rendón-Ochoa; Montserrat Padilla-Orozco; Vladimir Melesio Calderon; Victor Hugo Avilés-Rosas; Omar Hernández-González; Teresa Hernández-Flores; María Belén Perez-Ramirez; Marcela Palomero-Rivero; Elvira Galarraga; José Bargas
Journal: ASN Neuro Date: 2022 Jan-Dec Impact factor: 5.200

3. Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivo.

Authors: Tobias Gyárfás; Juha Knuuttila; Päivi Lindholm; Tomi Rantamäki; Eero Castrén
Journal: Cell Mol Neurobiol Date: 2009-09-24 Impact factor: 5.046

Review 4. G protein-coupled receptor heterocomplexes in neuropsychiatric disorders.

Authors: José L Moreno; Terrell Holloway; Javier González-Maeso
Journal: Prog Mol Biol Transl Sci Date: 2013 Impact factor: 3.622

Review 5. Allosteric Interactions between Adenosine A_2A and Dopamine D₂ Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging.

Authors: Kavya Prasad; Erik F J de Vries; Philip H Elsinga; Rudi A J O Dierckx; Aren van Waarde
Journal: Int J Mol Sci Date: 2021-02-09 Impact factor: 5.923

Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model.

1. The effects of systemic, intrastriatal, and intrapallidal injections of caffeine and systemic injections of A2A and A1 antagonists on forepaw stepping in the unilateral 6-OHDA-lesioned rat.

2. Dopamine D₂ and Adenosine A_2A Receptors Interaction on Ca²⁺ Current Modulation in a Rodent Model of Parkinsonism.

3. Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivo.

Review 4. G protein-coupled receptor heterocomplexes in neuropsychiatric disorders.

Review 5. Allosteric Interactions between Adenosine A_2A and Dopamine D₂ Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging.

Review 6. Adenosine 2A Receptor Antagonists for the Treatment of Motor Symptoms in Parkinson's Disease.

7. Optical deconstruction of parkinsonian neural circuitry.

Review 8. Targeting Adenosine Signaling in Parkinson's Disease: From Pharmacological to Non-pharmacological Approaches.

Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model.

1. The effects of systemic, intrastriatal, and intrapallidal injections of caffeine and systemic injections of A2A and A1 antagonists on forepaw stepping in the unilateral 6-OHDA-lesioned rat.

2. Dopamine D2 and Adenosine A2A Receptors Interaction on Ca2+ Current Modulation in a Rodent Model of Parkinsonism.

3. Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivo.

Review 4. G protein-coupled receptor heterocomplexes in neuropsychiatric disorders.

Review 5. Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging.

Review 6. Adenosine 2A Receptor Antagonists for the Treatment of Motor Symptoms in Parkinson's Disease.

7. Optical deconstruction of parkinsonian neural circuitry.

Review 8. Targeting Adenosine Signaling in Parkinson's Disease: From Pharmacological to Non-pharmacological Approaches.

2. Dopamine D₂ and Adenosine A_2A Receptors Interaction on Ca²⁺ Current Modulation in a Rodent Model of Parkinsonism.

Review 5. Allosteric Interactions between Adenosine A_2A and Dopamine D₂ Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging.