| Literature DB >> 17340256 |
Y B Tripathi1, O P Malhotra, S N Tripathi.
Abstract
A ketosteroid has been isolated from the oleo-resin of COMMIPHORA MUKUL and its structure (4,17(20)trans pregnandiene 3,16-dione; Z-guggulsterone) established from its physico-chemical properties, specially UV, IR, NMR and mass-spectra. The isolated ketosteroid showed a strong thyroid stimulatory action when administered to albino rats. Its administration (1 mg/100 g body weight) brought about an increase in iodine-uptake by thyroid and enhanced activities of thyroid peroxidase and protease as well as oxygen consumption by isolated slices of liver and biceps muscle.Entities:
Year: 1984 PMID： 17340256 DOI： 10.1055/s-2007-969626
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352