| Literature DB >> 17340014 |
Valentina P Gubskaya1, Lucia Sh Berezhnaya, Aidar T Gubaidullin, Irina I Faingold, Raisa A Kotelnikova, Nina P Konovalova, Vladimir I Morozov, Igor A Litvinov, Ildus A Nuretdinov.
Abstract
Two nitroxide methanofullerenes was synthesized for the first time, and their structures and biological activities studied. It was shown by X-ray single crystal analysis that the methanofullerene with two nitroxide groups forms a 1 : 2 inclusion complex with chloroform and has a nearly tetrahedral (diamond-like) arrangement of fullerene-fullerene interactions in the crystal. For the first time, it has been found that malonate nitroxide methanofullerene in combination with the known anticancer drug cyclophosphamide (CPA) shows high antitumor activity against leukemia P-388.Entities:
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Year: 2007 PMID： 17340014 DOI： 10.1039/b617892h
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876