| Literature DB >> 17339112 |
Lucie Guetzoyan1, Florence Ramiandrasoa, Hélène Dorizon, Christine Desprez, Alexandre Bridoux, Christophe Rogier, Bruno Pradines, Martine Perrée-Fauvet.
Abstract
A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against one chloroquine-sensitive strain (3D7) and three chloroquine-resistant strains [W2 (Indochina), Bre1 (Brazil) and FCR3 (Gambia)] of Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC50 <or= 0.20 microM.Entities:
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Year: 2007 PMID： 17339112 DOI： 10.1016/j.bmc.2007.02.022
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641