Literature DB >> 17339083

Does a mutated X-linked dominant transcriptional repressor gene explain mirror writing ability and synaesthesia?

Iain Mathewson1.   

Abstract

X-linked dominant conditions tend to present as two distinct sex-dependent phenotypes. Mirror writing ability and synaesthesia both appear to fall into this category. The existence of two different phenotypes in these two conditions is advanced as a reason associated with regarding their genetic mode of transmission as being X-linked dominant. The alternative autosomal mode cannot account for different male and female phenotypes. It is suggested that the gene for mirror writing ability, a trait linked to non-right-handedness, negates the normal process of left-lateralisation of language. Similarities between mirror writing ability and synaesthesia are documented and it is further suggested that these similarities can be explained if the genes for each condition are regarded as target genes for the same mutated X-linked dominant transcriptional repressor gene, possibly MeCP2.

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Year:  2007        PMID: 17339083     DOI: 10.1016/j.mehy.2006.09.075

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN: 0306-9877            Impact factor:   1.538


  1 in total

1.  Synesthesia, pseudo-synesthesia, and irritable bowel syndrome.

Authors:  Helen R Carruthers; Vivien Miller; Nicholas Tarrier; Peter J Whorwell
Journal:  Dig Dis Sci       Date:  2012-06       Impact factor: 3.199

  1 in total

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