Literature DB >> 1733807

Cloning and expression of IDDM-specific human autoantigens.

D U Rabin1, S M Pleasic, R Palmer-Crocker, J A Shapiro.   

Abstract

A DNA cloning approach was taken to identify islet cell protein antigens that are recognized specifically by insulin-dependent diabetes mellitus (IDDM) sera. A human islet cDNA library was generated and screened with diabetic sera. In this article, identification of two clones is described. Proteins expressed by these lambda phages appeared to react specifically with newly diagnosed diabetic sera. Islet cell antibody 12 (ICA12) was tested by Western blotting. ICA512 was not reactive with sera in the Western format but was specifically immunoprecipitated by diabetic sera from an Escherichia coli extract.

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Year:  1992        PMID： 1733807     DOI： 10.2337/diab.41.2.183

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  28 in total

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Review 4.  Prediction and prevention of type I diabetes.

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Review 5.  Superantigens in insulin-dependent diabetes mellitus.

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Authors:  M Solimena; R Dirkx; J M Hermel; S Pleasic-Williams; J A Shapiro; L Caron; D U Rabin
Journal:  EMBO J       Date:  1996-05-01       Impact factor: 11.598

7.  Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen.

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9.  Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.

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Journal:  Diabetol Metab Syndr       Date:  2009-12-04       Impact factor: 3.320
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