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Literature DB >> 17337782

Age-dependent alterations of the T cell repertoire and functional diversity of T cells of the aged.

Abstract

The aging immune system is characterized by the contraction of T cell receptor (TCR) diversity and the de novo expression of NKrelated receptors (NKR) on oligoclonal T cells. NKR+ T cells likely represent a secondary immune diversification as a biological adaptation of aging to ensure host defense despite shrinkage of the TCR repertoire. NKRs are expressed in various combinations even among TCR-identical cells, and are capable of triggering effector pathways in either TCR-independent or TCR-dependent fashion. Understanding the biology of NKR+ T cells will be pivotal to the development of strategies to enhance immunity in the elderly.

Entities: Gene

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Year: 2006 PMID： 17337782 DOI： 10.1385/IR:36:1:221

Source DB: PubMed Journal: Immunol Res ISSN： 0257-277X Impact factor: 2.829

49 in total

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2. Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets.

Authors: A Wack; A Cossarizza; S Heltai; D Barbieri; S D'Addato; C Fransceschi; P Dellabona; G Casorati
Journal: Int Immunol Date: 1998-09 Impact factor: 4.823

3. Age-related changes in human blood lymphocyte subpopulations. II. Varying kinetics of percentage and absolute count measurements.

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4. Distinct transcriptional control mechanisms of killer immunoglobulin-like receptors in natural killer (NK) and in T cells.

Authors: Jing Xu; Abbe N Vallejo; Yong Jiang; Cornelia M Weyand; Jörg J Goronzy
Journal: J Biol Chem Date: 2005-04-29 Impact factor: 5.157

Review 5. CD28 extinction in human T cells: altered functions and the program of T-cell senescence.

Authors: Abbe N Vallejo
Journal: Immunol Rev Date: 2005-06 Impact factor: 12.988

Review 6. Structure of killer cell immunoglobulin-like receptors and their recognition of the class I MHC molecules.

Authors: J C Boyington; A G Brooks; P D Sun
Journal: Immunol Rev Date: 2001-06 Impact factor: 12.988

7. Formation of the killer Ig-like receptor repertoire on CD4+CD28null T cells.

Authors: Melissa R Snyder; Lars-Olof Muegge; Chetan Offord; William M O'Fallon; Zeljko Bajzer; Cornelia M Weyand; Jörg J Goronzy
Journal: J Immunol Date: 2002-04-15 Impact factor: 5.422

Review 8. Cytokine-induced killer cells: NK-like T cells with cytotolytic specificity against leukemia.

Authors: Y C Linn; Kam M Hui
Journal: Leuk Lymphoma Date: 2003-09

9. Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection.

Authors: Ester M M van Leeuwen; Ester B M Remmerswaal; Mireille T M Vossen; Ajda T Rowshani; Pauline M E Wertheim-van Dillen; René A W van Lier; Ineke J M ten Berge
Journal: J Immunol Date: 2004-08-01 Impact factor: 5.422

10. Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1).

Authors: David Voehringer; Marie Koschella; Hanspeter Pircher
Journal: Blood Date: 2002-07-12 Impact factor: 22.113

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Review 4. Expansions of NK-like αβT cells with chronologic aging: novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells.

Authors: Abbe N Vallejo; Robert G Mueller; David L Hamel; Amanda Way; Jeffrey A Dvergsten; Patricia Griffin; Anne B Newman
Journal: Ageing Res Rev Date: 2010-10-12 Impact factor: 10.895