Literature DB >> 17337766

Dissecting the humoral immune response to simian immunodeficiency virus: mechanisms of antibody-mediated virus neutralization.

Jonathan D Steckbeck1, Kelly Stefano Cole.   

Abstract

The ultimate goal of an AIDS vaccine is to elicit potent cellular and humoral immune responses that will result in broadly enduring protective immunity. During the past several years, we have focused on characterizing the quantitative and qualitative properties of the antibody response, principally working to define the mechanism(s) of antibody-mediated neutralization in vitro. We have utilized a panel of monoclonal antibodies generated from monkeys infected with attenuated SIV for more than 8 mo to dissect the early events of virus infection involved in antibody-mediated neutralization. Presented herein are highlights from our studies that have identified potential mechanisms by which antibodies neutralize SIV in vitro.

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Year:  2006        PMID： 17337766      PMCID： PMC3357918          DOI： 10.1385/IR:36:1:51

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  40 in total

1.  CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.

Authors:  A Trkola; T Dragic; J Arthos; J M Binley; W C Olson; G P Allaway; C Cheng-Mayer; J Robinson; P J Maddon; J P Moore
Journal:  Nature       Date:  1996-11-14       Impact factor: 49.962

2.  Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodies.

Authors:  J P Moore; Q J Sattentau; R Wyatt; J Sodroski
Journal:  J Virol       Date:  1994-01       Impact factor: 5.103

3.  A general model for the surface glycoproteins of HIV and other retroviruses.

Authors:  W R Gallaher; J M Ball; R F Garry; A M Martin-Amedee; R C Montelaro
Journal:  AIDS Res Hum Retroviruses       Date:  1995-02       Impact factor: 2.205

4.  Synergistic neutralization of a chimeric SIV/HIV type 1 virus with combinations of human anti-HIV type 1 envelope monoclonal antibodies or hyperimmune globulins.

Authors:  A Li; T W Baba; J Sodroski; S Zolla-Pazner; M K Gorny; J Robinson; M R Posner; H Katinger; C F Barbas; D R Burton; T C Chou; R M Ruprecht
Journal:  AIDS Res Hum Retroviruses       Date:  1997-05-20       Impact factor: 2.205

5.  Maturation of the cellular and humoral immune responses to persistent infection in horses by equine infectious anemia virus is a complex and lengthy process.

Authors:  S A Hammond; S J Cook; D L Lichtenstein; C J Issel; R C Montelaro
Journal:  J Virol       Date:  1997-05       Impact factor: 5.103

6.  Passive immunization of rhesus macaques against SIV infection and disease.

Authors:  M Gardner; A Rosenthal; M Jennings; J Yee; L Antipa; E Robinson
Journal:  AIDS Res Hum Retroviruses       Date:  1995-07       Impact factor: 2.205

7.  Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus.

Authors:  J E Clements; R C Montelaro; M C Zink; A M Amedee; S Miller; A M Trichel; B Jagerski; D Hauer; L N Martin; R P Bohm
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

8.  Passive immune globulin therapy in the SIV/macaque model: early intervention can alter disease profile.

Authors:  N L Haigwood; A Watson; W F Sutton; J McClure; A Lewis; J Ranchalis; B Travis; G Voss; N L Letvin; S L Hu; V M Hirsch; P R Johnson
Journal:  Immunol Lett       Date:  1996-06       Impact factor: 3.685

9.  Simian immunodeficiency virus mutants resistant to serum neutralization arise during persistent infection of rhesus monkeys.

Authors:  D P Burns; C Collignon; R C Desrosiers
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103

10.  Effects of natural sequence variation on recognition by monoclonal antibodies neutralize simian immunodeficiency virus infectivity.

Authors:  W S Choi; C Collignon; C Thiriart; D P Burns; E J Stott; K A Kent; R C Desrosiers
Journal:  J Virol       Date:  1994-09       Impact factor: 5.103
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  2 in total

1.  Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography.

Authors:  Tommi A White; Alberto Bartesaghi; Mario J Borgnia; M Jason V de la Cruz; Rachna Nandwani; James A Hoxie; Julian W Bess; Jeffrey D Lifson; Jacqueline L S Milne; Sriram Subramaniam
Journal:  J Virol       Date:  2011-09-21       Impact factor: 5.103

2.  Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation.

Authors:  Lucrezia Colonna; Christopher W Peterson; John B Schell; Judith M Carlson; Victor Tkachev; Melanie Brown; Alison Yu; Sowmya Reddy; Willi M Obenza; Veronica Nelson; Patricia S Polacino; Heather Mack; Shiu-Lok Hu; Katie Zeleski; Michelle Hoffman; Joe Olvera; Scott N Furlan; Hengqi Zheng; Agne Taraseviciute; Daniel J Hunt; Kayla Betz; Jennifer F Lane; Keith Vogel; Charlotte E Hotchkiss; Cassie Moats; Audrey Baldessari; Robert D Murnane; Christopher English; Cliff A Astley; Solomon Wangari; Brian Agricola; Joel Ahrens; Naoto Iwayama; Andrew May; Laurence Stensland; Meei-Li W Huang; Keith R Jerome; Hans-Peter Kiem; Leslie S Kean
Journal:  Nat Commun       Date:  2018-10-25       Impact factor: 14.919
  2 in total

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