Literature DB >> 17337578

In vivo modulation of a DnaJ homolog, CbpA, by CbpM.

Matthew R Chenoweth1, Nancy Trun, Sue Wickner.   

Abstract

CbpA, an Escherichia coli DnaJ homolog, can function as a cochaperone for the DnaK/Hsp70 chaperone system, and its in vitro activity can be modulated by CbpM. We discovered that CbpM specifically inhibits the in vivo activity of CbpA, preventing it from functioning in cell growth and division. Furthermore, we have shown that CbpM interacts with CbpA in vivo during stationary phase, suggesting that the inhibition of activity is a result of the interaction. These results reveal that the activity of the E. coli DnaK system can be regulated in vivo by a specific inhibitor.

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Year:  2007        PMID： 17337578      PMCID： PMC1855902          DOI： 10.1128/JB.01757-06

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  17 in total

1.  An efficient recombination system for chromosome engineering in Escherichia coli.

Authors:  D Yu; H M Ellis; E C Lee; N A Jenkins; N G Copeland; D L Court
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

2.  Homogeneous expression of the P(BAD) promoter in Escherichia coli by constitutive expression of the low-affinity high-capacity AraE transporter.

Authors:  A Khlebnikov; K A Datsenko; T Skaug; B L Wanner; J D Keasling
Journal:  Microbiology       Date:  2001-12       Impact factor: 2.777

3.  DafA cycles between the DnaK chaperone system and translational machinery.

Authors:  Georgeta L Dumitru; Yvonne Groemping; Dagmar Klostermeier; Tobias Restle; Elke Deuerling; Jochen Reinstein
Journal:  J Mol Biol       Date:  2004-06-18       Impact factor: 5.469

4.  Functional analysis of CbpA, a DnaJ homolog and nucleoid-associated DNA-binding protein.

Authors:  Jeremy G Bird; Suveena Sharma; Sara C Roshwalb; Joel R Hoskins; Sue Wickner
Journal:  J Biol Chem       Date:  2006-09-14       Impact factor: 5.157

5.  Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter.

Authors:  L M Guzman; D Belin; M J Carson; J Beckwith
Journal:  J Bacteriol       Date:  1995-07       Impact factor: 3.490

6.  An analogue of the DnaJ molecular chaperone whose expression is controlled by sigma s during the stationary phase and phosphate starvation in Escherichia coli.

Authors:  T Yamashino; M Kakeda; C Ueguchi; T Mizuno
Journal:  Mol Microbiol       Date:  1994-08       Impact factor: 3.501

7.  An analogue of the DnaJ molecular chaperone in Escherichia coli.

Authors:  C Ueguchi; M Kakeda; H Yamada; T Mizuno
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205

8.  CbpA, a DnaJ homolog, is a DnaK co-chaperone, and its activity is modulated by CbpM.

Authors:  Chi Chae; Suveena Sharma; Joel R Hoskins; Sue Wickner
Journal:  J Biol Chem       Date:  2004-06-07       Impact factor: 5.157

9.  A study of the double mutation of dnaJ and cbpA, whose gene products function as molecular chaperones in Escherichia coli.

Authors:  C Ueguchi; T Shiozawa; M Kakeda; H Yamada; T Mizuno
Journal:  J Bacteriol       Date:  1995-07       Impact factor: 3.490

10.  Participation of Escherichia coli heat shock proteins DnaJ, DnaK, and GrpE in P1 plasmid replication.

Authors:  K Tilly; M Yarmolinsky
Journal:  J Bacteriol       Date:  1989-11       Impact factor: 3.490
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  8 in total

1.  Complex regulation of the DnaJ homolog CbpA by the global regulators sigmaS and Lrp, by the specific inhibitor CbpM, and by the proteolytic degradation of CbpM.

Authors:  Matthew R Chenoweth; Sue Wickner
Journal:  J Bacteriol       Date:  2008-05-23       Impact factor: 3.490

Review 2.  Proteolysis in the Escherichia coli heat shock response: a player at many levels.

Authors:  Anne S Meyer; Tania A Baker
Journal:  Curr Opin Microbiol       Date:  2011-02-24       Impact factor: 7.934

3.  CbpA acts as a modulator of HspR repressor DNA binding activity in Helicobacter pylori.

Authors:  Davide Roncarati; Alberto Danielli; Vincenzo Scarlato
Journal:  J Bacteriol       Date:  2011-08-12       Impact factor: 3.490

4.  DNA recognition by Escherichia coli CbpA protein requires a conserved arginine-minor-groove interaction.

Authors:  Kiran Chintakayala; Laura E Sellars; Shivani S Singh; Rajesh Shahapure; Ilja Westerlaken; Anne S Meyer; Remus T Dame; David C Grainger
Journal:  Nucleic Acids Res       Date:  2015-02-10       Impact factor: 16.971

5.  Dimerization and DNA-dependent aggregation of the Escherichia coli nucleoid protein and chaperone CbpA.

Authors:  Sarah Cosgriff; Kiran Chintakayala; Ya Tsz A Chim; Xinyong Chen; Stephanie Allen; Andrew L Lovering; David C Grainger
Journal:  Mol Microbiol       Date:  2010-09       Impact factor: 3.501

6.  Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes.

Authors:  Nadinath B Nillegoda; Antonia Stank; Duccio Malinverni; Niels Alberts; Anna Szlachcic; Alessandro Barducci; Paolo De Los Rios; Rebecca C Wade; Bernd Bukau
Journal:  Elife       Date:  2017-05-15       Impact factor: 8.140

7.  Conserved central domains control the quaternary structure of type I and type II Hsp40 molecular chaperones.

Authors:  Carlos H I Ramos; Cristiano L P Oliveira; Chung-Yang Fan; Iris L Torriani; Douglas M Cyr
Journal:  J Mol Biol       Date:  2008-08-14       Impact factor: 5.469

8.  Structure of CbpA J-domain bound to the regulatory protein Cbpm explains its specificity and suggests evolutionary link between Cbpm and transcriptional regulators.

Authors:  Naghmeh S Sarraf; Rong Shi; Laura McDonald; Jason Baardsnes; Linhua Zhang; Miroslaw Cygler; Irena Ekiel
Journal:  PLoS One       Date:  2014-06-19       Impact factor: 3.240
  8 in total

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