| Literature DB >> 17337162 |
Frank P MacMaster1, Rhonda El-Sheikh, Ameet R Upadhyaya, Jeffrey Nutche, David R Rosenberg, Matcheri Keshavan.
Abstract
The objective of this study was to examine the effect of antipsychotics on pituitary volume in schizophrenic subjects. Pituitary volumes were measured in 16 patients with schizophrenia at baseline and 12 months after treatment with an antipsychotic medication using magnetic resonance imaging (MRI). A group of 12 healthy controls was evaluated at baseline and after 12 months. Pituitary volume significantly increased in the schizophrenic subjects after treatment (12% increase). This appeared to be specific to the prolactin-elevating drugs. In controls, pituitary volume did not change significantly (3% decrease). Pituitary volume may be a useful biomarker for treatments that affect neuroendocrine function.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17337162 DOI： 10.1016/j.schres.2007.01.022
Source DB: PubMed Journal: Schizophr Res ISSN： 0920-9964 Impact factor: 4.939