| Literature DB >> 17336299 |
Vidya Rajesh1, M Elamaran, S Vidya, M Gowrishankar, Dhanpat Kochar, Ashis Das.
Abstract
Malaria parasites exhibit sequence diversity for a number of stage specific antigens. Several studies have proved that apical membrane antigen-1 (AMA-1) is an effective target for eliciting a protective immune response in humans and other experimental animals. We have investigated the sequence variation in Plasmodium vivax AMA-1 (Pv AMA-1) from different Indian isolates. This is the first study of its kind for the nearly full length Pv AMA-1 from India. Our analysis reveals greater degree of genetic diversity in Pv AMA-1 than reported so far and identifies five novel haplotypes. This is significant to establish the antigenic repertoire of isolates in a malaria endemic country like India.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17336299 DOI： 10.1016/j.exppara.2007.01.006
Source DB: PubMed Journal: Exp Parasitol ISSN： 0014-4894 Impact factor: 2.011