| Literature DB >> 17335547 |
A C A Devillers1, A W van Toorenenbergen, G J Klein Heerenbrink, P G H Muldert, A P Oranje.
Abstract
Matrix metalloproteinase (MMP)-9 has been shown to play a role in the infiltration of inflammatory cells in various tissues. It is thus part of the pathogenesis of many inflammatory diseases, including asthma and allergic rhinitis/conjunctivitis. We compared plasma MMP-9 levels of 20 patients with atopic dermatitis (AD) with that of 17 control subjects. Additional outcome parameters consisted of the modified objective SCORing Atopic Dermatitis and the Three Item Severity score in patients, and peripheral blood leucocytes and eosinophils in both groups. Plasma MMP-9 levels were found to be significantly higher in patients compared with controls, supporting a role for MMP-9 in the pathogenesis of AD.Entities:
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Year: 2007 PMID： 17335547 DOI： 10.1111/j.1365-2230.2007.02378.x
Source DB: PubMed Journal: Clin Exp Dermatol ISSN： 0307-6938 Impact factor: 3.470