Literature DB >> 17334777

Calcium-dependent transcription of cytokine genes in T lymphocytes.

Magali Savignac1, Britt Mellström, Jose R Naranjo.   

Abstract

The increase in intracellular calcium ion concentration is a general signaling mechanism used in many biological systems. In T lymphocytes, calcium is essential for activation, differentiation, and effector functions. In this study, we will summarize recent developments of how intracellular calcium concentrations are modified in T cells to affect the activity of three major calcium-dependent transcriptional effectors, i.e., NFAT, MEF2, and DREAM, involved in cytokine gene expression.

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Year:  2007        PMID： 17334777     DOI： 10.1007/s00424-007-0238-y

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  115 in total

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