Literature DB >> 17334499

Protein C inhibitor, a serpin with functions in- and outside vascular biology.

Margarethe Geiger1.   

Abstract

Human protein C inhibitor (PCI), a serpin-type protease inhibitor originally described as an inhibitor of activated protein C, has broad protease reactivity. In addition to its activities within the blood clotting and fibrinolytic cascades, it seems to participate in several biological processes including reproduction and tumor growth. This review summarizes the current understanding of PCI function, regulation, and potential biological role.

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Year:  2007        PMID： 17334499

Source DB:  PubMed          Journal:  Thromb Haemost        ISSN： 0340-6245            Impact factor:   5.249


  14 in total

1.  Effects of a Terrified-Sound Stress on Serum Proteomic Profiling in Mice.

Authors:  Juan Yang; Xin Zhang; Xiaofan Xiong; Qiuhua Wu; Lingyu Zhao; Liying Liu; Yannan Qin; Tusheng Song; Chen Huang
Journal:  J Mol Neurosci       Date:  2015-07-09       Impact factor: 3.444

2.  Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex.

Authors:  Wei Li; Ty E Adams; Jyoti Nangalia; Charles T Esmon; James A Huntington
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-24       Impact factor: 11.205

3.  Tumor biomarker glycoproteins in the seminal plasma of healthy human males are endogenous ligands for DC-SIGN.

Authors:  Gary F Clark; Paola Grassi; Poh-Choo Pang; Maria Panico; David Lafrenz; Erma Z Drobnis; Michael R Baldwin; Howard R Morris; Stuart M Haslam; Sophia Schedin-Weiss; Wei Sun; Anne Dell
Journal:  Mol Cell Proteomics       Date:  2011-10-10       Impact factor: 5.911

4.  SERPINA5 inhibits tumor cell migration by modulating the fibronectin-integrin β1 signaling pathway in hepatocellular carcinoma.

Authors:  Ying Jing; Deshui Jia; Chun-Ming Wong; Irene Oi-Lin Ng; Zhenfeng Zhang; Li Liu; Qifeng Wang; Fangyu Zhao; Jinjun Li; Ming Yao; Xingzhong Wu; Xianghuo He
Journal:  Mol Oncol       Date:  2013-12-18       Impact factor: 6.603

5.  Expression patterns of protein C inhibitor in mouse development.

Authors:  Gerry T M Wagenaar; Pavel Uhrin; Klara Weipoltshammer; Marlene Almeder; Pieter S Hiemstra; Margarethe Geiger; Joost C M Meijers; Christian Schöfer
Journal:  J Mol Histol       Date:  2010-03-14       Impact factor: 2.611

Review 6.  Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).

Authors:  Peter Goettig; Viktor Magdolen; Hans Brandstetter
Journal:  Biochimie       Date:  2010-07-06       Impact factor: 4.079

7.  Interaction of protein C inhibitor with the type II transmembrane serine protease enteropeptidase.

Authors:  Thomas A Prohaska; Felix C Wahlmüller; Margareta Furtmüller; Margarethe Geiger
Journal:  PLoS One       Date:  2012-06-19       Impact factor: 3.240

8.  Protein C inhibitor--a novel antimicrobial agent.

Authors:  Erik Malmström; Matthias Mörgelin; Martin Malmsten; Linda Johansson; Anna Norrby-Teglund; Oonagh Shannon; Artur Schmidtchen; Joost C M Meijers; Heiko Herwald
Journal:  PLoS Pathog       Date:  2009-12-18       Impact factor: 6.823

9.  Phosphatidylethanolamine critically supports internalization of cell-penetrating protein C inhibitor.

Authors:  Petra Baumgärtner; Margarethe Geiger; Susanne Zieseniss; Julia Malleier; James A Huntington; Karin Hochrainer; Edith Bielek; Mechthild Stoeckelhuber; Kirsten Lauber; Dag Scherfeld; Petra Schwille; Katja Wäldele; Klaus Beyer; Bernd Engelmann
Journal:  J Cell Biol       Date:  2007-11-19       Impact factor: 10.539

10.  An original SERPINA3 gene cluster: elucidation of genomic organization and gene expression in the Bos taurus 21q24 region.

Authors:  Patrick Pelissier; Didier Delourme; Agnes Germot; Xavier Blanchet; Samira Becila; Abderrahman Maftah; Hubert Leveziel; Ahmed Ouali; Laure Bremaud
Journal:  BMC Genomics       Date:  2008-04-02       Impact factor: 3.969
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