| Literature DB >> 17334376 |
Lucien Bettendorff1, Barbara Wirtzfeld, Alexander F Makarchikov, Gabriel Mazzucchelli, Michel Frédérich, Tiziana Gigliobianco, Marjorie Gangolf, Edwin De Pauw, Luc Angenot, Pierre Wins.
Abstract
Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.Entities:
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Year: 2007 PMID： 17334376 DOI： 10.1038/nchembio867
Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040