PROBLEM: As recent studies have suggested abnormalities in the regulation of specific genes in the development of endometriosis, we investigated differentially expressed genes in endometriosis compared to endometrium. METHOD OF STUDY: Gene expression profiles using the Atlas microarray were performed in endometriotic tissue and endometrium. Nine of the 13 genes of endometriotic tissue showed an up-regulation in relation to endometrium and four of the 13 genes a down-regulation. RESULTS: Of the 1176 genes on the Atlas Human 1,2 array, only 13 differentially expressed identical genes were detected after repeating the gene analysis three times. CONCLUSION: According to our c-DNA analysis some differentially expressed genes may be involved in the pathogenesis of endometriosis. An imbalance in the genes responsible for the reproductive process may lead to a decrease in embryo implantation in patients with endometriosis.
PROBLEM: As recent studies have suggested abnormalities in the regulation of specific genes in the development of endometriosis, we investigated differentially expressed genes in endometriosis compared to endometrium. METHOD OF STUDY: Gene expression profiles using the Atlas microarray were performed in endometriotic tissue and endometrium. Nine of the 13 genes of endometriotic tissue showed an up-regulation in relation to endometrium and four of the 13 genes a down-regulation. RESULTS: Of the 1176 genes on the Atlas Human 1,2 array, only 13 differentially expressed identical genes were detected after repeating the gene analysis three times. CONCLUSION: According to our c-DNA analysis some differentially expressed genes may be involved in the pathogenesis of endometriosis. An imbalance in the genes responsible for the reproductive process may lead to a decrease in embryo implantation in patients with endometriosis.
Authors: Christoph Loddenkemper; Sylvia Mechsner; Hans-Dieter Foss; Friederike E Dallenbach; Ioannis Anagnostopoulos; Andreas D Ebert; Harald Stein Journal: Am J Surg Pathol Date: 2003-11 Impact factor: 6.394
Authors: L C Kao; A Germeyer; S Tulac; S Lobo; J P Yang; R N Taylor; K Osteen; B A Lessey; L C Giudice Journal: Endocrinology Date: 2003-07 Impact factor: 4.736
Authors: Ali Salmassi; Bengi Acar-Perk; Andreas G Schmutzler; Kerstin Koch; Frank Püngel; Walter Jonat; Liselotte Mettler Journal: Bioimpacts Date: 2011-08-06
Authors: Antonio Simone Laganà; Simone Garzon; Martin Götte; Paola Viganò; Massimo Franchi; Fabio Ghezzi; Dan C Martin Journal: Int J Mol Sci Date: 2019-11-10 Impact factor: 5.923