Literature DB >> 17333096

Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation.

J L Zakrzewski1, A M Holland, M R M van den Brink.   

Abstract

Strategies to enhance post-transplant immune reconstitution without aggravating graft-vs-host disease (GVHD) can improve the outcome of allogeneic hematopoietic stem cell transplantation. Recent preclinical studies demonstrated that the use of T cell depleted allografts supplemented with committed progenitor cells (vs stem cells only) allows enhanced immune reconstitution of specific hematopoietic lineages including myeloid, B, T, and natural killer lineages in the absence of GVHD. This novel adoptive therapy resulted in significantly improved resistance to microbial pathogens and could, in some cases, even mediate tumor immunity. Clinical protocols using adoptive transfer of committed hematopoietic progenitor cells are currently being evaluated.

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Mesh：

Year:  2007        PMID： 17333096     DOI： 10.1007/s00109-007-0175-4

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  52 in total

1.  Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro.

Authors:  Thomas M Schmitt; Renée F de Pooter; Matthew A Gronski; Sarah K Cho; Pamela S Ohashi; Juan Carlos Zúñiga-Pflücker
Journal:  Nat Immunol       Date:  2004-03-21       Impact factor: 25.606

2.  Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation.

Authors:  Johannes L Zakrzewski; Adam A Kochman; Sydney X Lu; Theis H Terwey; Theo D Kim; Vanessa M Hubbard; Stephanie J Muriglan; David Suh; Odette M Smith; Jeremy Grubin; Neel Patel; Andrew Chow; Javier Cabrera-Perez; Radhika Radhakrishnan; Adi Diab; Miguel-Angel Perales; Gabrielle Rizzuto; Ewa Menet; Eric G Pamer; Glen Heller; Juan Carlos Zúñiga-Pflücker; Onder Alpdogan; Marcel R M van den Brink
Journal:  Nat Med       Date:  2006-08-27       Impact factor: 53.440

3.  Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration.

Authors:  Onder Alpdogan; Vanessa M Hubbard; Odette M Smith; Neel Patel; Sydney Lu; Gabrielle L Goldberg; Daniel H Gray; Jared Feinman; Adam A Kochman; Jeffrey M Eng; David Suh; Stephanie J Muriglan; Richard L Boyd; Marcel R M van den Brink
Journal:  Blood       Date:  2005-11-22       Impact factor: 22.113

4.  Prolonged immune deficiency following allogeneic stem cell transplantation: risk factors and complications in adult patients.

Authors:  S Maury; J Y Mary; C Rabian; M Schwarzinger; A Toubert; C Scieux; M Carmagnat; H Esperou; P Ribaud; A Devergie; P Guardiola; P Vexiau; D Charron; E Gluckman; G Socié
Journal:  Br J Haematol       Date:  2001-12       Impact factor: 6.998

5.  Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft.

Authors:  P Tiberghien; C Ferrand; B Lioure; N Milpied; R Angonin; E Deconinck; J M Certoux; E Robinet; P Saas; B Petracca; C Juttner; C W Reynolds; D L Longo; P Hervé; J Y Cahn
Journal:  Blood       Date:  2001-01-01       Impact factor: 22.113

6.  Human bone marrow CD34+ progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment.

Authors:  Magda De Smedt; Inge Hoebeke; Jean Plum
Journal:  Blood Cells Mol Dis       Date:  2004 Nov-Dec       Impact factor: 3.039

7.  T-cell depleted peripheral blood stem cell allotransplantation with T-cell add-back for patients with hematological malignancies: effect of chronic GVHD on outcome.

Authors:  Aldemar Montero; Bipin N Savani; Aarthi Shenoy; Elizabeth J Read; Charles S Carter; Susan F Leitman; Stephan Mielke; Katayoun Rezvani; Richard Childs; A John Barrett
Journal:  Biol Blood Marrow Transplant       Date:  2006-12       Impact factor: 5.742

8.  Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standard-risk leukaemias.

Authors:  D Maraninchi; E Gluckman; D Blaise; D Guyotat; B Rio; J L Pico; V Leblond; M Michallet; F Dreyfus; N Ifrah
Journal:  Lancet       Date:  1987-07-25       Impact factor: 79.321

9.  Insulin-like growth factor-I enhances lymphoid and myeloid reconstitution after allogeneic bone marrow transplantation.

Authors:  Onder Alpdogan; Stephanie J Muriglan; Barry J Kappel; Ekaterina Doubrovina; Cornelius Schmaltz; Raffaella Schiro; Jeffrey M Eng; Andrew S Greenberg; Lucy M Willis; Jimmy A Rotolo; Richard J O'Reilly; Marcel R M van den Brink
Journal:  Transplantation       Date:  2003-06-27       Impact factor: 4.939

10.  HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia.

Authors:  C Bonini; G Ferrari; S Verzeletti; P Servida; E Zappone; L Ruggieri; M Ponzoni; S Rossini; F Mavilio; C Traversari; C Bordignon
Journal:  Science       Date:  1997-06-13       Impact factor: 47.728
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  2 in total

Review 1.  Greater than the sum of their parts: combination strategies for immune regeneration following allogeneic hematopoietic stem cell transplantation.

Authors:  Jarrod A Dudakov; Marcel R M van den Brink
Journal:  Best Pract Res Clin Haematol       Date:  2011-06-29       Impact factor: 3.020

Review 2.  Enhancing T cell reconstitution after hematopoietic stem cell transplantation: a brief update of the latest trends.

Authors:  Johannes L Zakrzewski; Gabrielle L Goldberg; Odette M Smith; Marcel R M van den Brink
Journal:  Blood Cells Mol Dis       Date:  2007-10-01       Impact factor: 3.039
  2 in total

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