Literature DB >> 17333087

A paediatric supratentorial primitive neuroectodermal tumour associated with malignant astrocytic transformation and a clonal origin of both components.

Susanne A Kuhn1, Uwe-Karsten Hanisch, Kristian Ebmeier, Christian Beetz, Michael Brodhun, Rupert Reichart, Christian Ewald, Thomas Deufel, Rolf Kalff.   

Abstract

The case of a 7-year-old boy suffering from a supratentorial primitive neuroectodermal tumour (sPNET) at the age of 5 is presented. The tumour has been characterized by astrocytic areas within the sPNET revealing malignant transformation up to a multiform glioblastoma during the course of the disease. The clonal origin of both tumour components was established by loss of heterozygosity (LOH) analysis. Clinically, the tumour showed an aggressive biological behaviour with two recurrences. We discuss this very rare case and the first description of the clonal origin of distinct and distinguishable tumour components taking into consideration published literature.

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Mesh：

Year:  2007        PMID： 17333087     DOI： 10.1007/s10143-007-0069-5

Source DB:  PubMed          Journal:  Neurosurg Rev        ISSN： 0344-5607            Impact factor:   3.042


  37 in total

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Journal:  Neuro Oncol       Date:  1999-07       Impact factor: 12.300

Review 2.  Primary intracranial neoplasms of infancy and early childhood.

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Journal:  Childs Nerv Syst       Date:  1997-10       Impact factor: 1.475

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Journal:  Lab Invest       Date:  1989-12       Impact factor: 5.662

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Authors:  L P Dehner
Journal:  Arch Pathol Lab Med       Date:  1986-11       Impact factor: 5.534

Review 5.  Patterns of failure in relation to radiotherapy fields in supratentorial primitive neuroectodermal tumor.

Authors:  Arnold C Paulino; Daniel T Cha; Jerry L Barker; Simon Lo; Ricarchito B Manera
Journal:  Int J Radiat Oncol Biol Phys       Date:  2004-03-15       Impact factor: 7.038

6.  Primitive cerebral neuroectodermal tumors excluding medulloblastomas: a retrospective study of 30 cases.

Authors:  Y Mikaeloff; M A Raquin; A Lellouch-Tubiana; M J Terrier-Lacombe; M Zerah; C Bulteau; J L Habrand; C Kalifa
Journal:  Pediatr Neurosurg       Date:  1998-10       Impact factor: 1.162

7.  Prognostic factors and treatment results for supratentorial primitive neuroectodermal tumors in children using radiation and chemotherapy: a Childrens Cancer Group randomized trial.

Authors:  B H Cohen; P M Zeltzer; J M Boyett; J R Geyer; J C Allen; J L Finlay; P McGuire-Cullen; J M Milstein; L B Rorke; P Stanley
Journal:  J Clin Oncol       Date:  1995-07       Impact factor: 44.544

8.  Coexpression of platelet-derived growth factor alpha and beta receptors on medulloblastomas and other primitive neuroectodermal tumors is consistent with an immature stem cell and neuronal derivation.

Authors:  A Smits; D van Grieken; M Hartman; U Lendahl; K Funa; M Nistér
Journal:  Lab Invest       Date:  1996-01       Impact factor: 5.662

9.  Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: a SEER update. Surveillance Epidemiology and End Results.

Authors:  Dawn Elizabeth McNeil; Timothy R Coté; Limin Clegg; Lucy Balian Rorke
Journal:  Med Pediatr Oncol       Date:  2002-09

Review 10.  Medulloblastomas and central nervous system primitive neuroectodermal tumors.

Authors:  Thomas W McLean
Journal:  Curr Treat Options Oncol       Date:  2003-12
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