BACKGROUND AND OBJECTIVES: Infectious pathogens in blood are a potential source of transmission of hepatitis B and C, human immunodeficiency virus (HIV) and syphilis. The present study reviews the frequency of these infections in volunteer and replacement blood donors in Lahore, Pakistan. METHODS: Data on serologic testing of blood donors (using commercial assays) were reviewed for the years 1996-2005. Data from 2004 and 2005 were also analyzed with respect to age and type of donor (volunteer versus replacement). RESULTS: The frequency of serologic evidence of various infectious pathogens ranged as follows: hepatitis B 1.46-2.99%, with a downward trend over time, hepatitis C 3.01-4.99%, HIV 0-0.06%, and syphilis 0.19-0.57%. Amongst replacement donors, younger individuals (<35 years) had lower seroprevalence of hepatitis markers as compared to older persons. Overall, volunteer donors (6.98% of all donors) had the lowest seroprevalence for the diseases. CONCLUSIONS: The frequency of hepatitis C amongst Pakistani donors is the highest in the region while that of hepatitis B is declining gradually. Volunteer donors have lower frequencies of tested infections compared to replacement donors. Compared to neighboring India, syphilis occurs with a similar frequency but HIV is seen less commonly.
BACKGROUND AND OBJECTIVES: Infectious pathogens in blood are a potential source of transmission of hepatitis B and C, human immunodeficiency virus (HIV) and syphilis. The present study reviews the frequency of these infections in volunteer and replacement blood donors in Lahore, Pakistan. METHODS: Data on serologic testing of blood donors (using commercial assays) were reviewed for the years 1996-2005. Data from 2004 and 2005 were also analyzed with respect to age and type of donor (volunteer versus replacement). RESULTS: The frequency of serologic evidence of various infectious pathogens ranged as follows: hepatitis B 1.46-2.99%, with a downward trend over time, hepatitis C 3.01-4.99%, HIV 0-0.06%, and syphilis 0.19-0.57%. Amongst replacement donors, younger individuals (<35 years) had lower seroprevalence of hepatitis markers as compared to older persons. Overall, volunteer donors (6.98% of all donors) had the lowest seroprevalence for the diseases. CONCLUSIONS: The frequency of hepatitis C amongst Pakistani donors is the highest in the region while that of hepatitis B is declining gradually. Volunteer donors have lower frequencies of tested infections compared to replacement donors. Compared to neighboring India, syphilis occurs with a similar frequency but HIV is seen less commonly.