Literature DB >> 17331646

Dose dependence and therapeutic window for the neuroprotective effects of 17beta-estradiol when administered after cerebral ischemia.

Ran Liu1, Xiaofei Wang, Qing Liu, Shao-Hua Yang, James W Simpkins.   

Abstract

The present study was undertaken to determine if the neuroprotective effect of 17beta-estradiol (E(2)) when administrated after ischemia is dose-dependent and if the therapeutic window for estrogen can be prolonged. Ischemic injury was induced by permanent middle cerebral artery occlusion (p-MCAO). Administration of E(2) at 30 min after ischemia resulted in a reduction in lesion volume. A higher dose of E(2) extended the therapeutic window to 6h after cerebral ischemia in 33% of the rats. These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window.

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Year:  2007        PMID： 17331646      PMCID： PMC1936945          DOI： 10.1016/j.neulet.2007.01.074

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  31 in total

1.  Estradiol exerts neuroprotective effects when administered after ischemic insult.

Authors:  S H Yang; J Shi; A L Day; J W Simpkins
Journal:  Stroke       Date:  2000-03       Impact factor: 7.914

Review 2.  Mitochondria play a central role in estrogen-induced neuroprotection.

Authors:  James W Simpkins; Jian Wang; Xiaofei Wang; Evelyn Perez; Laszlo Prokai; James A Dykens
Journal:  Curr Drug Targets CNS Neurol Disord       Date:  2005-02

3.  Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke.

Authors:  L D McCullough; N J Alkayed; R J Traystman; M J Williams; P D Hurn
Journal:  Stroke       Date:  2001-03       Impact factor: 7.914

Review 4.  Estrogen as a neuroprotectant in stroke.

Authors:  P D Hurn; I M Macrae
Journal:  J Cereb Blood Flow Metab       Date:  2000-04       Impact factor: 6.200

5.  17beta-estradiol reduces stroke injury in estrogen-deficient female animals.

Authors:  R Rusa; N J Alkayed; B J Crain; R J Traystman; A S Kimes; E D London; J A Klaus; P D Hurn
Journal:  Stroke       Date:  1999-08       Impact factor: 7.914

6.  Neuroprotective effects of estradiol in middle-aged female rats.

Authors:  D B Dubal; P M Wise
Journal:  Endocrinology       Date:  2001-01       Impact factor: 4.736

7.  The nonfeminizing enantiomer of 17beta-estradiol exerts protective effects in neuronal cultures and a rat model of cerebral ischemia.

Authors:  P S Green; S H Yang; K R Nilsson; A S Kumar; D F Covey; J W Simpkins
Journal:  Endocrinology       Date:  2001-01       Impact factor: 4.736

Review 8.  Neuroprotective effects of estrogens: potential mechanisms of action.

Authors:  P S Green; J W Simpkins
Journal:  Int J Dev Neurosci       Date:  2000 Jul-Aug       Impact factor: 2.457

9.  17-beta estradiol can reduce secondary ischemic damage and mortality of subarachnoid hemorrhage.

Authors:  S H Yang; Z He; S S Wu; Y J He; J Cutright; W J Millard; A L Day; J W Simpkins
Journal:  J Cereb Blood Flow Metab       Date:  2001-02       Impact factor: 6.200

10.  Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury.

Authors:  D B Dubal; H Zhu; J Yu; S W Rau; P J Shughrue; I Merchenthaler; M S Kindy; P M Wise
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-06       Impact factor: 11.205
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  19 in total

Review 1.  Revisiting the timing hypothesis: biomarkers that define the therapeutic window of estrogen for stroke.

Authors:  Farida Sohrabji; Amutha Selvamani; Robyn Balden
Journal:  Horm Behav       Date:  2012-06-19       Impact factor: 3.587

2.  Effect of different doses of estrogen on the nigrostriatal dopaminergic system in two 6-hydroxydopamine-induced lesion models of Parkinson's disease.

Authors:  Marcela Ferreira Cordellini; Giovana Piazzetta; Karin Cristine Pinto; Ana Márcia Delattre; Francesca Matheussi; Ruither O G Carolino; Raphael Escorsim Szawka; Janete A Anselmo-Franci; Anete Curte Ferraz
Journal:  Neurochem Res       Date:  2011-02-24       Impact factor: 3.996

Review 3.  Neuroprotective actions of estradiol and novel estrogen analogs in ischemia: translational implications.

Authors:  Anne M Etgen; Teresa Jover-Mengual; R Suzanne Zukin
Journal:  Front Neuroendocrinol       Date:  2010-12-14       Impact factor: 8.606

Review 4.  Neuroprotective action of acute estrogens: animal models of brain ischemia and clinical implications.

Authors:  Tomoko Inagaki; Anne M Etgen
Journal:  Steroids       Date:  2013-02-04       Impact factor: 2.668

5.  Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke.

Authors:  Ran Liu; Qing Liu; Shaoqing He; James W Simpkins; Shao-Hua Yang
Journal:  J Pharmacol Exp Ther       Date:  2009-12-01       Impact factor: 4.030

6.  Buyang Huanwu Decoction () reduces infarct volume and enhances estradiol and estradiol receptor concentration in ovariectomized rats after middle cerebral artery occlusion.

Authors:  Bai-yan Liu; Xiao-ling Song; Jian Yi; Xue-mei Chen; Yue Yu; Hui Liu; Guang-xian Cai
Journal:  Chin J Integr Med       Date:  2014-08-07       Impact factor: 1.978

7.  Different methods for administering 17beta-estradiol to ovariectomized rats result in opposite effects on ischemic brain damage.

Authors:  Jakob O Strom; Elvar Theodorsson; Lovisa Holm; Annette Theodorsson
Journal:  BMC Neurosci       Date:  2010-03-17       Impact factor: 3.288

8.  High-dose estrogen treatment at reperfusion reduces lesion volume and accelerates recovery of sensorimotor function after experimental ischemic stroke.

Authors:  Randall S Carpenter; Ifeanyi Iwuchukwu; Cyrus L Hinkson; Sydney Reitz; Wonhee Lee; Ayaka Kukino; An Zhang; Martin M Pike; Agnieszka A Ardelt
Journal:  Brain Res       Date:  2016-03-17       Impact factor: 3.252

9.  Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling.

Authors:  Joshua W Gatson; David L Maass; James W Simpkins; Ahamed H Idris; Joseph P Minei; Jane G Wigginton
Journal:  J Neuroinflammation       Date:  2009-10-22       Impact factor: 8.322

10.  Acute administration of non-classical estrogen receptor agonists attenuates ischemia-induced hippocampal neuron loss in middle-aged female rats.

Authors:  Diane Lebesgue; Michael Traub; Maxine De Butte-Smith; Christopher Chen; R Suzanne Zukin; Martin J Kelly; Anne M Etgen
Journal:  PLoS One       Date:  2010-01-08       Impact factor: 3.240
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