| Literature DB >> 17331551 |
James McNulty1, Jerald J Nair, Carles Codina, Jaume Bastida, Siyaram Pandey, Jenny Gerasimoff, Carly Griffin.
Abstract
The selective apoptosis-inducing activity of Amaryllidaceae alkaloids belonging to the crinane-type is reported. A mini-library of natural and synthetic crinane alkaloids was assembled. Biological screening indicated crinamine 4 and haemanthamine 9 to be potent inducers of apoptosis in tumour cells at micromolar concentrations. Structure-activity relationships demonstrated the requirement for both an alpha-C2 bridge and a free hydroxyl at the C-11 position as pharmacophoric requirements for this activity.Entities:
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Year: 2007 PMID： 17331551 DOI： 10.1016/j.phytochem.2007.01.006
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072