| Literature DB >> 17331504 |
Ana M San Gabriel1, Takami Maekawa, Hisayuki Uneyama, Sumio Yoshie, Kunio Torii.
Abstract
l-glutamate not only confers cognitive discrimination for umami taste in the oral cavity, but also conveys sensory information to vagal afferent fibers in the gastric mucosa. We used RT-PCR, western blotting, and immunohistochemistry to demonstrate that mGluR1 is located in glandular stomach. Double staining revealed that mGluR1 is found at the apical membrane of chief cells and possibly in parietal cells. Moreover, a diet with 1% l-glutamate induced changes in the expression of pepsinogen C mRNA in stomach mucosa. These data suggest that mGluR1 is involved in the gastric phase regulation of protein digestion.Entities:
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Year: 2007 PMID： 17331504 DOI： 10.1016/j.febslet.2007.02.016
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124