| Literature DB >> 17331036 |
Ka-Cheung Luk1, Vera Holzmayer, Julie Yamaguchi, Priscilla Swanson, Catherine A Brennan, Charlotte Ngansop, Dora Mbanya, Hermine Gayum, Marcelline Ngounoue Djuidje, Nicaise Ndembi, Donatien Kamdem, Lazare Kaptué, Lutz Gürtler, Sushil G Devare, John Hackett.
Abstract
Recombinant forms of HIV-1 contribute significantly to the ongoing epidemic. In the present study, we characterized the near full-length genomes of three candidate HIV-1 CRF13_cpx strains originating in Cameroon, 04CM-173-9, 04CM-632-28, and 02CM-A1394. Bootscanning, recombination breakpoint analysis, and phylogenetic trees confirmed similar genomic structures with identical breakpoint positions compared to the three available CRF13_cpx sequences. The candidate and reference sequences formed a distinct cluster well separated from other group M subtypes and had a mosaic structure derived from subtypes A1, G, J, and CRF01_AE. The similarity in genomic composition and position of recombination breakpoints suggest that these isolates share a common ancestor. The epidemiological significance of CRF13_cpx strains in Cameroon is unknown; however, the availability of three additional genomic sequences will improve our understanding of the overall genetic diversity within this recombinant form of HIV-1.Entities:
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Year: 2007 PMID： 17331036 DOI： 10.1089/aid.2006.0177
Source DB: PubMed Journal: AIDS Res Hum Retroviruses ISSN： 0889-2229 Impact factor: 2.205