| Literature DB >> 17330951 |
Martin H Maurer1, Jens O Brömme, Robert E Feldmann, Anne Järve, Fatemeh Sabouri, Heinrich F Bürgers, Dominik W Schelshorn, Carola Krüger, Armin Schneider, Wolfgang Kuschinsky.
Abstract
On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3beta (GSK3beta) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/beta-catenin signaling pathway appear to participate in enhanced neuronal differentiation and activated transcription of beta-catenin target genes during GSK3beta inhibition, associated with decreased apoptosis.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17330951 DOI： 10.1021/pr0605825
Source DB: PubMed Journal: J Proteome Res ISSN： 1535-3893 Impact factor: 4.466