| Literature DB >> 17328987 |
Jason H Bielas1, Ranga N Venkatesan, Lawrence A Loeb.
Abstract
Cancers are thought to originate in stem cells through the accumulation of multiple mutations. Some of these mutations result in a loss of heterozygosity (LOH). A recent report demonstrates that exposure of mouse embryonic stem cells to nontoxic amounts of mutagens triggers a marked increase in the frequency of LOH. Thus, mutagen induction of LOH in embryonic stem cells suggests a new pathway to account for the multiple homozygous mutations in human tumors. This induction could mimic early mutagenic events that generate cancers in human tissue stem cells.Entities:
Mesh：
Year: 2007 PMID： 17328987 DOI： 10.1016/j.tig.2007.02.009
Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639