Literature DB >> 17328532

(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors.

Kyeong Lee1, Jeong Hyung Lee, Shanthaveerappa K Boovanahalli, Yinglan Jin, Mijeoung Lee, Xuejun Jin, Jin Hwan Kim, Young-Soo Hong, Jung Joon Lee.   

Abstract

Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1alpha protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.

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Year:  2007        PMID： 17328532     DOI： 10.1021/jm0610292

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  44 in total

1.  Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein.

Authors:  Stéphane Betzi; Audrey Restouin; Sandrine Opi; Stefan T Arold; Isabelle Parrot; Françoise Guerlesquin; Xavier Morelli; Yves Collette
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-27       Impact factor: 11.205

2.  HIF1α and pancreatic β-cell development.

Authors:  Mylène Heinis; Andrea Soggia; Camille Bechetoille; Marie-Thérèse Simon; Carole Peyssonnaux; Pierre Rustin; Raphael Scharfmann; Bertrand Duvillié
Journal:  FASEB J       Date:  2012-03-16       Impact factor: 5.191

3.  Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia.

Authors:  Neha Gupta; Anita Sahu; Amit Prabhakar; Tathagata Chatterjee; Tarun Tyagi; Babita Kumari; Nilofar Khan; Velu Nair; Nitin Bajaj; Manish Sharma; Mohammad Zahid Ashraf
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-18       Impact factor: 11.205

4.  Interdependence of HIF-1α and TGF-β/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression.

Authors:  Rajit K Basu; Susan Hubchak; Tomoko Hayashida; Constance E Runyan; Paul T Schumacker; H William Schnaper
Journal:  Am J Physiol Renal Physiol       Date:  2011-01-05

5.  Hypoxic expression of NLRP3 and VEGF in cultured retinal pigment epithelial cells: contribution of P2Y2 receptor signaling.

Authors:  Fabian Doktor; Philipp Prager; Peter Wiedemann; Leon Kohen; Andreas Bringmann; Margrit Hollborn
Journal:  Purinergic Signal       Date:  2018-11-10       Impact factor: 3.765

6.  Osmotic induction of placental growth factor in retinal pigment epithelial cells in vitro: contribution of NFAT5 activity.

Authors:  Margrit Hollborn; Konrad Reichmuth; Philipp Prager; Peter Wiedemann; Andreas Bringmann; Leon Kohen
Journal:  Mol Biol Rep       Date:  2016-05-26       Impact factor: 2.316

7.  Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells.

Authors:  Shibo Fu; Moses Tarndie Tar; Arnold Melman; Kelvin Paul Davies
Journal:  FASEB J       Date:  2014-05-06       Impact factor: 5.191

8.  Osmotic expression of aldose reductase in retinal pigment epithelial cells: involvement of NFAT5.

Authors:  Anica Winges; Tarcyane Barata Garcia; Philipp Prager; Peter Wiedemann; Leon Kohen; Andreas Bringmann; Margrit Hollborn
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2016-09-14       Impact factor: 3.117

9.  Design and in vitro activities of N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, novel, small-molecule hypoxia inducible factor-1 pathway inhibitors and anticancer agents.

Authors:  Jiyoung Mun; Adnan Abdul Jabbar; Narra Sarojini Devi; Shaoman Yin; Yingzhe Wang; Chalet Tan; Deborah Culver; James P Snyder; Erwin G Van Meir; Mark M Goodman
Journal:  J Med Chem       Date:  2012-07-24       Impact factor: 7.446

10.  Heregulin/ErbB3 Signaling Enhances CXCR4-Driven Rac1 Activation and Breast Cancer Cell Motility via Hypoxia-Inducible Factor 1α.

Authors:  Cynthia Lopez-Haber; Laura Barrio-Real; Victoria Casado-Medrano; Marcelo G Kazanietz
Journal:  Mol Cell Biol       Date:  2016-07-14       Impact factor: 4.272
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