Ji-yao Jiang1, Xiao-feng Yang. 1. Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, P.R.China. Jiangjyb@online.sh.cn
Abstract
PURPOSE OF REVIEW: The aim of this article is to review the current status of protective effects of mild-to-moderate hypothermia on traumatic brain injury. RECENT FINDINGS: More than 30 clinical studies have reported effects of therapeutic hypothermia on outcome of traumatic brain injury and cerebral ischemia. Only one clinical trial of short-term mild hypothermia did not show any effect in patients with severe traumatic brain injury. Long-term mild hypothermia may be useful for severe traumatic brain-injured patients. SUMMARY: Mild-to-moderate hypothermia plays a significant role in cerebral protection after traumatic brain injury.
PURPOSE OF REVIEW: The aim of this article is to review the current status of protective effects of mild-to-moderate hypothermia on traumatic brain injury. RECENT FINDINGS: More than 30 clinical studies have reported effects of therapeutic hypothermia on outcome of traumatic brain injury and cerebral ischemia. Only one clinical trial of short-term mild hypothermia did not show any effect in patients with severe traumatic brain injury. Long-term mild hypothermia may be useful for severe traumatic brain-injuredpatients. SUMMARY: Mild-to-moderate hypothermia plays a significant role in cerebral protection after traumatic brain injury.
Authors: Marek Ma; Brian T Matthews; Joshua W Lampe; David F Meaney; Frances S Shofer; Robert W Neumar Journal: Exp Neurol Date: 2008-10-11 Impact factor: 5.330