Literature DB >> 1732697

Pituitary adenylate cyclase activating polypeptide stimulates insulin release from the isolated perfused rat pancreas.

K Kawai1, C Ohse, Y Watanabe, S Suzuki, K Yamashita, S Ohashi.   

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP) is a novel hypothalamic peptide structurally related to vasoactive intestinal peptide (VIP) and glucagon like peptide-1(7-36) amide (tGLP-1) in its N-terminal portion. Therefore, their levels of insulinotropic potency were compared using an isolated rat pancreas perfusion. It was found that 0.1 nM PACAP (1-27) amide (PACAP27) significantly stimulated insulin release under a perfusate glucose concentration of 5.5 mM, whereas 1 nM PACAP27 did not under a perfusate glucose concentration of 2.8 mM. The potency was evaluated as tGLP-1 greater than PACAP27 greater than VIP. These results indicate that PACAP is a glucagon superfamily peptide which stimulates insulin release in a glucose dependent manner.

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Year:  1992        PMID： 1732697     DOI： 10.1016/0024-3205(92)90332-j

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  10 in total

Review 1.  Trophic effects of PACAP on pancreatic islets: a mini-review.

Authors:  Yusuke Sakurai; Norihito Shintani; Atsuko Hayata; Hitoshi Hashimoto; Akemichi Baba
Journal:  J Mol Neurosci       Date:  2010-07-20       Impact factor: 3.444

2.  PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance.

Authors:  F Jamen; K Persson; G Bertrand; N Rodriguez-Henche; R Puech; J Bockaert; B Ahrén; P Brabet
Journal:  J Clin Invest       Date:  2000-05       Impact factor: 14.808

3.  Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and lipotoxicity.

Authors:  Masanori Nakata; Norihito Shintani; Hitoshi Hashimoto; Akemichi Baba; Toshihiko Yada
Journal:  J Mol Neurosci       Date:  2010-05-12       Impact factor: 3.444

4.  Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet substance serving as an intra-islet amplifier of glucose-induced insulin secretion in rats.

Authors:  T Yada; M Sakurada; H Ishihara; M Nakata; S Shioda; K Yaekura; N Hamakawa; K Yanagida; M Kikuchi; Y Oka
Journal:  J Physiol       Date:  1997-12-01       Impact factor: 5.182

5.  Comparative effects of PACAP and VIP on pancreatic endocrine secretions and vascular resistance in rat.

Authors:  G Bertrand; R Puech; Y Maisonnasse; J Bockaert; M M Loubatières-Mariani
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

6.  Pituitary adenylate cyclase-activating polypeptide (PACAP): occurrence in rodent pancreas and effects on insulin and glucagon secretion in the mouse.

Authors:  T Fridolf; F Sundler; B Ahrén
Journal:  Cell Tissue Res       Date:  1992-08       Impact factor: 5.249

7.  PACAP regulates immediate catecholamine release from adrenal chromaffin cells in an activity-dependent manner through a protein kinase C-dependent pathway.

Authors:  Barbara A Kuri; Shyue-An Chan; Corey B Smith
Journal:  J Neurochem       Date:  2009-06-05       Impact factor: 5.372

8.  Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells.

Authors:  N Inagaki; H Yoshida; M Mizuta; N Mizuno; Y Fujii; T Gonoi; J Miyazaki; S Seino
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-29       Impact factor: 11.205

9.  VPAC1 receptor expression in peripheral blood mononuclear cells in a human endotoxemia model.

Authors:  Angela Storka; Bernhard Burian; Gerhard Führlinger; Breanna Clive; Terri Sun; Richard Crevenna; Andrea Gsur; Wilhelm Mosgöller; Michael Wolzt
Journal:  J Transl Med       Date:  2013-05-07       Impact factor: 5.531

10.  Pituitary adenylate cyclase activating peptide (PACAP) participates in adipogenesis by activating ERK signaling pathway.

Authors:  Tatjana Arsenijevic; Françoise Gregoire; Jeanne Chiadak; Elodie Courtequisse; Nargis Bolaky; Jason Perret; Christine Delporte
Journal:  PLoS One       Date:  2013-09-09       Impact factor: 3.240
  10 in total

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