Literature DB >> 17325813

Mito-DEPMPO synthesized from a novel NH2-reactive DEPMPO spin trap: a new and improved trap for the detection of superoxide.

Micael Hardy1, Florence Chalier, Olivier Ouari, Jean-Pierre Finet, Antal Rockenbauer, Balaraman Kalyanaraman, Paul Tordo.   

Abstract

Mito-DEPMPO, a new DEPMPO analogue bearing a triphenylphosphonium group, was synthesized via a novel NH2-reactive DEPMPO. The half-life of the Mito-DEPMPO superoxide adduct was estimated to be ca. 40 min. Using Mito-DEPMPO, reactive oxygen species generated in intact mitochondria were detected and characterized by EPR.

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Year:  2007        PMID： 17325813     DOI： 10.1039/b616076j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  15 in total

1.  A targetable fluorescent sensor reveals that copper-deficient SCO1 and SCO2 patient cells prioritize mitochondrial copper homeostasis.

Authors:  Sheel C Dodani; Scot C Leary; Paul A Cobine; Dennis R Winge; Christopher J Chang
Journal:  J Am Chem Soc       Date:  2011-05-12       Impact factor: 15.419

Review 2.  Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics.

Authors:  Frederick A Villamena; Amlan Das; Kevin M Nash
Journal:  Future Med Chem       Date:  2012-06       Impact factor: 3.808

Review 3.  Detection and Characterization of Reactive Oxygen and Nitrogen Species in Biological Systems by Monitoring Species-Specific Products.

Authors:  Micael Hardy; Jacek Zielonka; Hakim Karoui; Adam Sikora; Radosław Michalski; Radosław Podsiadły; Marcos Lopez; Jeannette Vasquez-Vivar; Balaraman Kalyanaraman; Olivier Ouari
Journal:  Antioxid Redox Signal       Date:  2017-11-17       Impact factor: 8.401

Review 4.  Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications.

Authors:  Jacek Zielonka; Joy Joseph; Adam Sikora; Micael Hardy; Olivier Ouari; Jeannette Vasquez-Vivar; Gang Cheng; Marcos Lopez; Balaraman Kalyanaraman
Journal:  Chem Rev       Date:  2017-06-27       Impact factor: 60.622

Review 5.  Nutritional countermeasures targeting reactive oxygen species in cancer: from mechanisms to biomarkers and clinical evidence.

Authors:  Anatoly Samoylenko; Jubayer Al Hossain; Daniela Mennerich; Sakari Kellokumpu; Jukka Kalervo Hiltunen; Thomas Kietzmann
Journal:  Antioxid Redox Signal       Date:  2013-04-15       Impact factor: 8.401

6.  Lipophilic beta-cyclodextrin cyclic-nitrone conjugate: synthesis and spin trapping studies.

Authors:  Yongbin Han; Yangping Liu; Antal Rockenbauer; Jay L Zweier; Grégory Durand; Frederick A Villamena
Journal:  J Org Chem       Date:  2009-08-07       Impact factor: 4.354

7.  A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells.

Authors:  Bryan C Dickinson; Christopher J Chang
Journal:  J Am Chem Soc       Date:  2008-07-08       Impact factor: 15.419

8.  Nitrones for understanding and ameliorating the oxidative stress associated with aging.

Authors:  Siham El Fangour; Milvia Marini; James Good; Stephen J McQuaker; Paul G Shiels; Richard C Hartley
Journal:  Age (Dordr)       Date:  2009-12

9.  Synthesis of a mitochondria-targeted spin trap using a novel Parham-type cyclization.

Authors:  Caroline Quin; Jan Trnka; Alison Hay; Michael P Murphy; Richard C Hartley
Journal:  Tetrahedron       Date:  2009-09-26       Impact factor: 2.457

10.  Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants.

Authors:  Linsey Robertson; Richard C Hartley
Journal:  Tetrahedron       Date:  2009-07-04       Impact factor: 2.457
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