| Literature DB >> 17325276 |
L Guyant-Maréchal1, A Rovelet-Lecrux, L Goumidi, E Cousin, D Hannequin, G Raux, C Penet, S Ricard, S Macé, P Amouyel, J-F Deleuze, T Frebourg, A Brice, J-C Lambert, D Campion.
Abstract
We genotyped five polymorphisms, including two polymorphisms with known effects on transcriptional activity, in a large cohort of 427 Alzheimer disease (AD) cases and 472 control subjects. An association between rs463946 (-3102 G/C) and AD was found and was confirmed in a replication sample of a similar size. By contrast, analysis of three recently described rare mutations influencing APP transcription did not confirm their association with AD risk.Entities:
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Year: 2007 PMID： 17325276 DOI： 10.1212/01.wnl.0000255938.33739.46
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910