Literature DB >> 17325226

A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole.

Shaoji Cheng1, Cornelius J Clancy, Katherine T Nguyen, William Clapp, M Hong Nguyen.   

Abstract

We showed that a Candida albicans petite mutant in which oxidative phosphorylation is uncoupled was eightfold more resistant to fluconazole and voriconazole than SC5314 but equally susceptible to ketoconazole, itraconazole, and amphotericin B. Strain P5 significantly overexpressed MDR1, which likely accounts for the decreased drug susceptibility.

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Year:  2007        PMID： 17325226      PMCID： PMC1855545          DOI： 10.1128/AAC.00182-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  40 in total

Review 1.  Mechanisms of antifungal agent resistance.

Authors:  Y L Yang; H J Lo
Journal:  J Microbiol Immunol Infect       Date:  2001-06       Impact factor: 4.399

2.  Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors.

Authors:  K W Henry; J T Nickels; T D Edlind
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191

3.  Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans.

Authors:  Patrick Marichal; Luc Koymans; Staf Willemsens; Danny Bellens; Peter Verhasselt; Walter Luyten; Marcel Borgers; Frans C S Ramaekers; Frank C Odds; Hugo Vanden Bossche
Journal:  Microbiology       Date:  1999-10       Impact factor: 2.777

4.  Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata.

Authors:  D Sanglard; F Ischer; J Bille
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

5.  Uncoupling of oxidative phosphorylation enables Candida albicans to resist killing by phagocytes and persist in tissue.

Authors:  Shaoji Cheng; Cornelius J Clancy; Zongde Zhang; Binghua Hao; Wei Wang; Kenneth A Iczkowski; Michael A Pfaller; M Hong Nguyen
Journal:  Cell Microbiol       Date:  2006-09-20       Impact factor: 3.715

6.  Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates.

Authors:  S Wirsching; S Michel; J Morschhäuser
Journal:  Mol Microbiol       Date:  2000-05       Impact factor: 3.501

7.  Resistance mechanisms in clinical isolates of Candida albicans.

Authors:  Theodore C White; Scott Holleman; Francis Dy; Laurence F Mirels; David A Stevens
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

8.  A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole.

Authors:  D Calabrese; J Bille; D Sanglard
Journal:  Microbiology       Date:  2000-11       Impact factor: 2.777

9.  In-vivo selection of an azole-resistant petite mutant of Candida glabrata.

Authors:  Jean-Philippe Bouchara; Rachid Zouhair; Sandrine LE Boudouil; Gilles Renier; Robert Filmon; Dominique Chabasse; Jean-Noel Hallet; Alain Defontaine
Journal:  J Med Microbiol       Date:  2000-11       Impact factor: 2.472

Review 10.  The genetic basis of fluconazole resistance development in Candida albicans.

Authors:  Joachim Morschhäuser
Journal:  Biochim Biophys Acta       Date:  2002-07-18
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  27 in total

1.  Mitochondrial sorting and assembly machinery subunit Sam37 in Candida albicans: insight into the roles of mitochondria in fitness, cell wall integrity, and virulence.

Authors:  Yue Qu; Branka Jelicic; Filomena Pettolino; Andrew Perry; Tricia L Lo; Victoria L Hewitt; Farkad Bantun; Traude H Beilharz; Anton Y Peleg; Trevor Lithgow; Julianne T Djordjevic; Ana Traven
Journal:  Eukaryot Cell       Date:  2012-01-27

Review 2.  Xenobiotic efflux in bacteria and fungi: a genomics update.

Authors:  Ravi D Barabote; Jose Thekkiniath; Richard E Strauss; Govindsamy Vediyappan; Joe A Fralick; Michael J San Francisco
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  2011

Review 3.  Mitochondria and fungal pathogenesis: drug tolerance, virulence, and potential for antifungal therapy.

Authors:  Miguel Shingu-Vazquez; Ana Traven
Journal:  Eukaryot Cell       Date:  2011-09-16

4.  Activity of Isavuconazole and Other Azoles against Candida Clinical Isolates and Yeast Model Systems with Known Azole Resistance Mechanisms.

Authors:  Dominique Sanglard; Alix T Coste
Journal:  Antimicrob Agents Chemother       Date:  2015-10-19       Impact factor: 5.191

5.  Inhibition of electron transport chain assembly and function promotes photodynamic killing of Candida.

Authors:  Yeissa Chabrier-Roselló; Benjamin R Giesselman; Francisco J De Jesús-Andino; Thomas H Foster; Soumya Mitra; Constantine G Haidaris
Journal:  J Photochem Photobiol B       Date:  2010-03-21       Impact factor: 6.252

Review 6.  Molecular and genetic basis of azole antifungal resistance in the opportunistic pathogenic fungus Candida albicans.

Authors:  Andrew T Nishimoto; Cheshta Sharma; P David Rogers
Journal:  J Antimicrob Chemother       Date:  2020-02-01       Impact factor: 5.790

7.  Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants.

Authors:  Nuo Sun; William Fonzi; Hui Chen; Xiaodong She; Lulu Zhang; Lixin Zhang; Richard Calderone
Journal:  Antimicrob Agents Chemother       Date:  2012-11-12       Impact factor: 5.191

8.  Microbiological screening of Irish patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy reveals persistence of Candida albicans strains, gradual reduction in susceptibility to azoles, and incidences of clinical signs of oral candidiasis without culture evidence.

Authors:  Brenda A McManus; Eleanor McGovern; Gary P Moran; Claire M Healy; June Nunn; Pádraig Fleming; Colm Costigan; Derek J Sullivan; David C Coleman
Journal:  J Clin Microbiol       Date:  2011-03-02       Impact factor: 5.948

9.  A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata.

Authors:  Patrick Vandeputte; Guy Tronchin; Gérald Larcher; Emilie Ernoult; Thierry Bergès; Dominique Chabasse; Jean-Philippe Bouchara
Journal:  Antimicrob Agents Chemother       Date:  2008-08-11       Impact factor: 5.191

10.  Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth.

Authors:  Patrick Vandeputte; Guy Tronchin; Françoise Rocher; Gilles Renier; Thierry Bergès; Dominique Chabasse; Jean-Philippe Bouchara
Journal:  Antimicrob Agents Chemother       Date:  2009-04-20       Impact factor: 5.191
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