| Literature DB >> 1732520 |
A H Lewin1, Y G Gao, P Abraham, J W Boja, M J Kuhar, F I Carroll.
Abstract
The potencies of a series of 2 beta-substituted cocaine analogues to displace [3H]-3 beta-(p-fluorophenyl)tropane-2 beta-carboxylic acid methyl ester binding in rat striatal membranes demonstrate the requirement for a 2 beta-substituent with two hydrogen-bond acceptors. The insensitivity of the ester moiety to steric and electronic factors suggests its modification to provide site-specific irreversible ligands.Entities:
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Year: 1992 PMID： 1732520 DOI： 10.1021/jm00079a017
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446