| Literature DB >> 17324606 |
Leonardo Fainboim1, Alejandra Cherñavsky, Natalia Paladino, Ana C Flores, Lourdes Arruvito.
Abstract
From an immunological point of view, the healthy liver has been usually associated with the phenomenon of tolerance. A microenvironment of regulatory cytokines produced by liver Kuppfer cells and liver sinusoidal endothelial cells has contributed, together with resident dendritic cells, to generate a tolerogenic environment in this tissue. In this review we discussed the intrahepatic responses to different sorts of liver injury, such as hepatotrophic viruses, alcohol or putative self-antigens. In each case we analyzed the impact of different cytokines in the clinical outcome of the different pathological situations.Entities:
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Year: 2007 PMID： 17324606 DOI： 10.1016/j.cytogfr.2007.01.017
Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638