BACKGROUND/AIM: Tobacco use reduces the effect of non-surgical periodontal therapy. Host-modulation with low-dose doxycycline (LDD) might favour repair and promote an improved treatment response. The aim of this study was to investigate the effect of LDD in smokers on non-surgical periodontal therapy. MATERIAL AND METHODS: This was a parallel arm, randomized, identical placebo-controlled trial with masking of examiner, care-giver, participant and statistician and 6 months of follow-up. Patients received non-surgical therapy and 3 months of test or control drug. Statistical analysis used both conventional methods and multilevel modelling. RESULTS:Eighteen control and 16 test patients completed the study. The velocity of change was statistically greater for the test group for clinical attachment level -0.19 mm/month (95% CI=-0.34, 0.04; p=0.012) and probing depth 0.30 mm/month (95% CI=-0.42, -0.17; p<0.001). However, no differences were observed for absolute change in clinical or biochemical markers at 6 months. CONCLUSIONS: This study does not provide evidence of a benefit of using LDD as an adjunct to non-surgical periodontal therapy in smokers.
RCT Entities:
BACKGROUND/AIM: Tobacco use reduces the effect of non-surgical periodontal therapy. Host-modulation with low-dose doxycycline (LDD) might favour repair and promote an improved treatment response. The aim of this study was to investigate the effect of LDD in smokers on non-surgical periodontal therapy. MATERIAL AND METHODS: This was a parallel arm, randomized, identical placebo-controlled trial with masking of examiner, care-giver, participant and statistician and 6 months of follow-up. Patients received non-surgical therapy and 3 months of test or control drug. Statistical analysis used both conventional methods and multilevel modelling. RESULTS: Eighteen control and 16 test patients completed the study. The velocity of change was statistically greater for the test group for clinical attachment level -0.19 mm/month (95% CI=-0.34, 0.04; p=0.012) and probing depth 0.30 mm/month (95% CI=-0.42, -0.17; p<0.001). However, no differences were observed for absolute change in clinical or biochemical markers at 6 months. CONCLUSIONS: This study does not provide evidence of a benefit of using LDD as an adjunct to non-surgical periodontal therapy in smokers.
Authors: K F Al-Shammari; W V Giannobile; W A Aldredge; V J Iacono; R M Eber; H L Wang; R J Oringer Journal: J Periodontol Date: 2001-08 Impact factor: 6.993
Authors: R J Oringer; K F Al-Shammari; W A Aldredge; V J Iacono; R M Eber; H L Wang; B Berwald; R Nejat; W V Giannobile Journal: J Periodontol Date: 2002-08 Impact factor: 6.993
Authors: Ahmad M Al-Bashaireh; Linda G Haddad; Michael Weaver; Debra Lynch Kelly; Xing Chengguo; Saunjoo Yoon Journal: J Environ Public Health Date: 2018-07-11