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Literature DB >> 17323963

Ag+ -assisted hydrosilylation: complementary behavior of Rh and Ir catalysts (reversal of enantioselectivity).

Abstract

[structure: see text]. The presence of a suitably situated hydroxy function in a PHOX ligand leads to an enhancement of the enantioselectivity in Rh-catalyzed hydrosilylations of prochiral ketones in the presence of AgBF4 (95% ee for acetophenone as compared to 75% using i-Pr-phosphinooxazoline (PHOX)). Exchanging Rh for Ir affords the product with the opposite absolute configuration (78% ee).

Entities: Chemical

Year: 2007 PMID： 17323963 DOI： 10.1021/ol0702730

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

1 in total

1. Synthesis and Exploration of Electronically Modified (R)-5,5-Dimethyl-(p-CF₃)₃-i-PrPHOX in Palladium-Catalyzed Enantio- and Diastereoselective Allylic Alkylation: A Practical Alternative to (R)-(p-CF₃)₃-t-BuPHOX.

Authors: Robert A Craig; Brian M Stoltz
Journal: Tetrahedron Lett Date: 2015-08-05 Impact factor: 2.415

1 in total

Ag+ -assisted hydrosilylation: complementary behavior of Rh and Ir catalysts (reversal of enantioselectivity).

1. Synthesis and Exploration of Electronically Modified (R)-5,5-Dimethyl-(p-CF3)3-i-PrPHOX in Palladium-Catalyzed Enantio- and Diastereoselective Allylic Alkylation: A Practical Alternative to (R)-(p-CF3)3-t-BuPHOX.

1. Synthesis and Exploration of Electronically Modified (R)-5,5-Dimethyl-(p-CF₃)₃-i-PrPHOX in Palladium-Catalyzed Enantio- and Diastereoselective Allylic Alkylation: A Practical Alternative to (R)-(p-CF₃)₃-t-BuPHOX.