| Literature DB >> 17323645 |
Hideaki Ui1, Kazuro Shiomi, Hideaki Suzuki, Hiroko Hatano, Hiromi Morimoto, Yuichi Yamaguchi, Rokuro Masuma, Toshiaki Sunazuka, Hiroyuki Shimamura, Kimitoshi Sakamoto, Kiyoshi Kita, Hideto Miyoshi, Hiroshi Tomoda, Satoshi Omura.
Abstract
A new NADH-fumarate reductase inhibitor, verticipyrone, was isolated from the cultured broth of a fungus, Verticillium sp. FKI-1083. The structure was established as (E)-2-methoxy-3,5-dimethyl-6-(3-methyl-2-undecenyl)-4H-pyran-4-one. Verticipyrone exhibited an IC50 value of 0.88 nM against NADH-fumarate reductase of Ascaris suum. Verticipyrone inhibited both Ascaris and bovine heart complex I, and its synthetic analogue, 8,9-dihydro-8-hydroxyverticipyrone, showed good selectivity against Ascaris complex I.Entities:
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Year: 2006 PMID： 17323645 DOI： 10.1038/ja.2006.103
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649