Literature DB >> 1732303

Cyclosporin and the gingival tissues.

R A Seymour1, D J Jacobs.   

Abstract

Cyclosporin is a selective immunosuppressant that has a variety of applications in medical practice. Like phenytoin and the calcium channel blockers, the drug is associated with gingival overgrowth. This review considers the pharmacokinetics, pharmacodynamics, uses and unwanted effects of cyclosporin, in particular the action of the drug on the gingival tissues. Clinical and cell culture studies suggest that the mechanism of gingival overgrowth is a result of an interaction between the drug and its metabolites with susceptible gingival fibroblasts. Plaque-induced gingival inflammation appears to enhance this interaction.

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Year:  1992        PMID： 1732303     DOI： 10.1111/j.1600-051x.1992.tb01140.x

Source DB:  PubMed          Journal:  J Clin Periodontol        ISSN： 0303-6979            Impact factor:   8.728


  15 in total

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