OBJECTIVE: Endothelial progenitor cells (EPCs) may have an important role in vascular homeostasis and repair. METHODS: We examined the level of circulating EPCs in pre- (n = 22; mean age 28.7 years), and postmenopausal healthy females without (n = 30; mean age 61.6 years) or under current hormone replacement therapy (HRT) (n = 19; mean age 59.8 years). RESULTS: Premenopausal females had the highest level of circulating EPCs (0.147 +/- 0.076 per thousand of polymorphnuclear cells). The level of EPCs was lowest in postmenopausal females (0.094 +/- 0.058 per thousand), and increased significantly with HRT on average by 25.5%. In addition, the proliferative capacity of circulating EPCs was assessed under cell culture conditions. This capacity was significantly increased in EPCs isolated from postmenopausal subjects under current HRT as compared to corresponding samples obtained from postmenopausal females without HRT. CONCLUSIONS: This observation is in line with the hypothesis that the hormonal status in females modulates the cardiovascular risk and that circulating EPCs could be involved in this phenomenon.
OBJECTIVE: Endothelial progenitor cells (EPCs) may have an important role in vascular homeostasis and repair. METHODS: We examined the level of circulating EPCs in pre- (n = 22; mean age 28.7 years), and postmenopausal healthy females without (n = 30; mean age 61.6 years) or under current hormone replacement therapy (HRT) (n = 19; mean age 59.8 years). RESULTS: Premenopausal females had the highest level of circulating EPCs (0.147 +/- 0.076 per thousand of polymorphnuclear cells). The level of EPCs was lowest in postmenopausal females (0.094 +/- 0.058 per thousand), and increased significantly with HRT on average by 25.5%. In addition, the proliferative capacity of circulating EPCs was assessed under cell culture conditions. This capacity was significantly increased in EPCs isolated from postmenopausal subjects under current HRT as compared to corresponding samples obtained from postmenopausal females without HRT. CONCLUSIONS: This observation is in line with the hypothesis that the hormonal status in females modulates the cardiovascular risk and that circulating EPCs could be involved in this phenomenon.
Authors: T Asahara; T Murohara; A Sullivan; M Silver; R van der Zee; T Li; B Witzenbichler; G Schatteman; J M Isner Journal: Science Date: 1997-02-14 Impact factor: 47.728
Authors: T Takahashi; C Kalka; H Masuda; D Chen; M Silver; M Kearney; M Magner; J M Isner; T Asahara Journal: Nat Med Date: 1999-04 Impact factor: 53.440
Authors: Kerstin Strehlow; Nikos Werner; Jan Berweiler; Andreas Link; Ulrich Dirnagl; Josef Priller; Kerstin Laufs; Leyli Ghaeni; Milan Milosevic; Michael Böhm; Georg Nickenig Journal: Circulation Date: 2003-06-16 Impact factor: 29.690
Authors: Daniel Bulut; Michael Scheeler; Lisa Marie Niedballa; Thomas Miebach; Andreas Mügge Journal: Clin Res Cardiol Date: 2011-02-06 Impact factor: 5.460
Authors: Gian Paolo Fadini; Mattia Albiero; Andrea Cignarella; Chiara Bolego; Christian Pinna; Elisa Boscaro; Elisa Pagnin; Renzo De Toni; Saula de Kreutzenberg; Carlo Agostini; Angelo Avogaro Journal: Clin Sci (Lond) Date: 2009-09-07 Impact factor: 6.124
Authors: Meijing Wang; Jiangning Tan; Arthur Coffey; John Fehrenbacher; Brent R Weil; Daniel R Meldrum Journal: J Thorac Cardiovasc Surg Date: 2009-07 Impact factor: 5.209
Authors: Míriam Navarro-Sobrino; Mar Hernández-Guillamon; Israel Fernandez-Cadenas; Marc Ribó; Ignacio A Romero; Pierre-Olivier Couraud; Babette Barbash Weksler; Joan Montaner; Anna Rosell Journal: Vasc Cell Date: 2013-02-06
Authors: Annelien C de Kat; Hendrik Gremmels; Marianne C Verhaar; Frank J M Broekmans; Felicia Yarde Journal: Int J Endocrinol Date: 2016-08-29 Impact factor: 3.257