OBJECTIVE: To investigate the efficacy and early complications of mitomycin C (MMC) in tracheal wound models. STUDY DESIGN AND SETTING: Rabbits (N = 60) were randomized to undergo mucosal injuries to the upper and lower trachea including anterior 120 degrees full thickness (group A, n = 20), anterior 120 degrees partial thickness (group B, 20), and circumferential partial thickness (group C, 20). In each rabbit, the wounds were separately treated with MMC 1.0 mg/mL or saline, and the animals were sacrificed after three weeks. RESULTS: Twenty-seven of the 60 animals experienced early death because of tracheal rupture or airway obstruction caused by unresolved scabs on the preinjured tracheal mucosa; the incidence of early death was higher in groups A and C than in group B. In each group, the degree of tracheal stenosis was comparable in wounds treated with MMC and saline. CONCLUSION: These findings suggest that topical MMC has no benefit when used to prevent tracheal stenosis. Acute airway obstruction may occur in MMC-treated rabbits with tracheal wounds.
OBJECTIVE: To investigate the efficacy and early complications of mitomycin C (MMC) in tracheal wound models. STUDY DESIGN AND SETTING:Rabbits (N = 60) were randomized to undergo mucosal injuries to the upper and lower trachea including anterior 120 degrees full thickness (group A, n = 20), anterior 120 degrees partial thickness (group B, 20), and circumferential partial thickness (group C, 20). In each rabbit, the wounds were separately treated with MMC 1.0 mg/mL or saline, and the animals were sacrificed after three weeks. RESULTS: Twenty-seven of the 60 animals experienced early death because of tracheal rupture or airway obstruction caused by unresolved scabs on the preinjured tracheal mucosa; the incidence of early death was higher in groups A and C than in group B. In each group, the degree of tracheal stenosis was comparable in wounds treated with MMC and saline. CONCLUSION: These findings suggest that topical MMC has no benefit when used to prevent tracheal stenosis. Acute airway obstruction may occur in MMC-treated rabbits with tracheal wounds.
Authors: J Raúl Olmos-Zuñiga; Matilde Baltazares-Lipp; Claudia Hernández-Jiménez; Rogelio Jasso-Victoria; Miguel Gaxiola-Gaxiola; Mariana Silva-Martínez; Marco Antonio Iñiguez-García; A Ivan González-González; Juan Carlos Vázquez-Minero; Antonia Luna-Flores; Norma Solis-Alanis; Mario Enrique Baltazares-Lipp Journal: Biomed Res Int Date: 2020-08-27 Impact factor: 3.411
Authors: Carlos Aravena; Francisco A Almeida; Sanjay Mukhopadhyay; Subha Ghosh; Robert R Lorenz; Sudish C Murthy; Atul C Mehta Journal: J Thorac Dis Date: 2020-03 Impact factor: 3.005