Literature DB >> 17321640

Synthesis and biological properties of 4-(3H)-quinazolone derivatives.

Anjani K Tiwari1, Vinay Kumar Singh, Aruna Bajpai, Gauri Shukla, Sweta Singh, Anil K Mishra.   

Abstract

A new quinazolone series has been designed, and synthesized by the anthranilic acid and different acid derivatives. Their structures have been elucidated on the basis of elemental analyses and spectral studies (IR, (1)H NMR, FT-IR and FAB-MS). A preliminary radiolabelling study with technetium has shown a very good future prospect for further evaluation in vivo. The biological activities (antifungal, antibacterial as well as anticancerous) of the evaluated compounds are discussed in this article.

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Year:  2007        PMID: 17321640     DOI: 10.1016/j.ejmech.2007.01.002

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN: 0223-5234            Impact factor:   6.514


  6 in total

1.  Synthesis and cytotoxic evaluation of some quinazolinone- 5-(4-chlorophenyl) 1, 3, 4-oxadiazole conjugates.

Authors:  Farshid Hassanzadeh; Hojjat Sadeghi-Aliabadi; Elham Jafari; Azadeh Sharifzadeh; Nasim Dana
Journal:  Res Pharm Sci       Date:  2019-10-04

2.  Synthesis and cytotoxicity evaluation of some new 6-nitro derivatives of thiazole-containing 4-(3H)-quinazolinone.

Authors:  Leila Hosseinzadeh; Alireza Aliabadi; Masoud Kalantari; Abolfazl Mostafavi; Marzieh Rahmani Khajouei
Journal:  Res Pharm Sci       Date:  2016 May-Jun

3.  Synthesis, SAR Study and Evaluation of Mannich and Schiff Bases of Pyrazol-5(4H)-one Moiety Containing 3-(Hydrazinyl)-2-phenylquinazolin-4(3H)-one.

Authors:  K K Sivakumar; A Rajasekharan; R Rao; B Narasimhan
Journal:  Indian J Pharm Sci       Date:  2013-07       Impact factor: 0.975

4.  Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents.

Authors:  Walaa S El-Serwy; Neama A Mohamed; Emad M M Kassem; Khaled Mahmoud; M M Mounier
Journal:  Iran J Pharm Res       Date:  2016       Impact factor: 1.696

5.  Synthesis and cytotoxic evaluation of some new 3-(2-(2-phenylthiazol-4-yl) ethyl)-quinazolin-4(3H) one derivatives with potential anticancer effects.

Authors:  Leila Hosseinzadeh; Alireza Aliabadi; Mohsen Rahnama; Hamid Mir Mohammad Sadeghi; Marzieh Rahmani Khajouei
Journal:  Res Pharm Sci       Date:  2017-08

6.  Synthesis and anticonvulsant activity of some quinazolin-4-(3H)-one derivatives.

Authors:  Hanan Georgey; Nagwa Abdel-Gawad; Safinaz Abbas
Journal:  Molecules       Date:  2008       Impact factor: 4.411

  6 in total

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