Literature DB >> 17321042

Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice.

Xiaoying Zhang1, Vipra Kundoor, Sherief Khalifa, David Zeman, Hesham Fahmy, Chandradhar Dwivedi.   

Abstract

The objective of this study was to determine the chemopreventive effects of sarcophine-diol (SD) on 7,12-dimethylbenz(a)anthracene initiated and 12-O-tetradecanoylphorbol-13-acetate promoted skin tumor development in mice and its possible mechanisms of action. SD pretreatment significantly (P<0.05) decreased skin papilloma development during promotion phase. SD significantly (P<0.05) increased caspase-3 and decreased cyclooxygenase-2 during initiation phase or promotion phase. SD significantly (P<0.05) increased caspase-8 during promotion phase. SD resulted in a 95% reduction in 12-O-tetradecanoylphorbol-13-acetate-induced DNA synthesis. SD could be an effective chemopreventive agent for skin cancer by enhancing apoptosis and decreasing cell proliferation.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17321042     DOI： 10.1016/j.canlet.2007.01.009

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  7 in total

Review 1.  Novel investigational drugs for basal cell carcinoma.

Authors:  Po-Lin So; Jean Y Tang; Ervin H Epstein
Journal:  Expert Opin Investig Drugs       Date:  2010-09       Impact factor: 6.206

2.  Chemopreventive effects of sarcophine-diol on ultraviolet B-induced skin tumor development in SKH-1 hairless mice.

Authors:  Xiaoying Zhang; Ajay Bommareddy; Wei Chen; Michael B Hildreth; Radhey S Kaushik; David Zeman; Sherief Khalifa; Hesham Fahmy; Chandradhar Dwivedi
Journal:  Mar Drugs       Date:  2009-04-30       Impact factor: 5.118

3.  Sarcophine-diol, a Chemopreventive Agent of Skin Cancer, Inhibits Cell Growth and Induces Apoptosis through Extrinsic Pathway in Human Epidermoid Carcinoma A431 Cells.

Authors:  Xiaoying Zhang; Ajay Bommareddy; Wei Chen; Sherief Khalifa; Radhey S Kaushik; Hesham Fahmy; Chandradhar Dwivedi
Journal:  Transl Oncol       Date:  2009-03       Impact factor: 4.243

4.  Sarcophine-diol, a skin cancer chemopreventive agent, inhibits proliferation and stimulates apoptosis in mouse melanoma B₁₆F₁₀ cell line.

Authors:  Pawel T Szymanski; Bhimanna Kuppast; Safwat A Ahmed; Sherief Khalifa; Hesham Fahmy
Journal:  Mar Drugs       Date:  2011-12-22       Impact factor: 6.085

5.  Sarcophine-diol inhibits expression of COX-2, inhibits activity of cPLA2, enhances degradation of PLA2 and PLC(γ)1 and inhibits cell membrane permeability in mouse melanoma B16F10 cells.

Authors:  Pawel T Szymanski; Pratik Muley; Safwat A Ahmed; Sherief Khalifa; Hesham Fahmy
Journal:  Mar Drugs       Date:  2012-09-28       Impact factor: 6.085

6.  Dose-response on the chemopreventive effects of sarcophine-diol on UVB-induced skin tumor development in SKH-1 hairless mice.

Authors:  Ruth F Guillermo; Xiaoying Zhang; Radhey S Kaushik; David Zeman; Safwat A Ahmed; Sherief Khalifa; Hesham Fahmy; Chandradhar Dwivedi
Journal:  Mar Drugs       Date:  2012-09-24       Impact factor: 6.085

7.  Chemopreventive effects of sarcotriol on ultraviolet B-induced skin tumor development in SKH-1 hairless mice.

Authors:  Vipra Kundoor; Xiaoying Zhang; Ajay Bommareddy; Sherief Khalifa; Hesham Fahmy; Chandradhar Dwivedi
Journal:  Mar Drugs       Date:  2007-12-12       Impact factor: 5.118
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.