| Literature DB >> 17320952 |
Gyula Végso1, Anna Sebestyén, Sándor Paku, Gábor Barna, Melinda Hajdu, Mária Tóth, Jeno Járay, László Kopper.
Abstract
Mycophenolic acid (MPA)/mycophenolate mofetil (MMF), a powerful immunosuppressive agent was tested on human B-lymphoma cells (Epstein-Barr virus +/-) in vitro and in SCID mouse xenograft model. Proliferation, apoptotic activity and tumor volume were evaluated. MPA inhibited lymphoma cell proliferation and induced apoptosis (50-60% at 72 h). In vivo, oral administration significantly inhibited subcutaneous tumor growth. Immunohistochemistry showed significantly decreased proliferation rate and higher apoptotic activity in tumors treated with MMF. Xenografted lymphoma cells remained sensitive to MPA. Our results suggest that MPA may be recommended as an additional component of lymphoma chemotherapeutical regimens, with special considerations to post-transplant lymphomas.Entities:
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Year: 2007 PMID： 17320952 DOI： 10.1016/j.leukres.2006.12.019
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156