BACKGROUND: Our goals were to examine the impact of neoadjuvant chemoradiation for rectal cancer on surgical outcomes and to determine prognostic factors predicting improved survival. METHODS: Retrospective cohort of 56 male and 44 female patients. RESULTS: After preoperative chemoradiation, 73% of patients had sphincter-preserving surgery. The 5-year disease-free (DFS) and overall survival rates were 77% and 81%, respectively. Twenty-five percent of patients showed a complete pathologic response. T-level downstaging and pathologic T stage did not correlate with recurrence or survival rates. Pathologic nodal stage was associated with a significant difference in recurrence rates (N(0) 19%, N1 20%, and N2 75%, P = .038) and DFS (N0/N1 vs. N2, 79% vs. 25%, P = .002). CONCLUSION: Neoadjuvant chemoradiation resulted in a high rate of sphincter preservation. Complete pathologic responses after surgery were frequent and although pathologic T stage after surgery did not affect recurrence rates, pathologic nodal response was associated with improved recurrence and survival rates.
BACKGROUND: Our goals were to examine the impact of neoadjuvant chemoradiation for rectal cancer on surgical outcomes and to determine prognostic factors predicting improved survival. METHODS: Retrospective cohort of 56 male and 44 female patients. RESULTS: After preoperative chemoradiation, 73% of patients had sphincter-preserving surgery. The 5-year disease-free (DFS) and overall survival rates were 77% and 81%, respectively. Twenty-five percent of patients showed a complete pathologic response. T-level downstaging and pathologic T stage did not correlate with recurrence or survival rates. Pathologic nodal stage was associated with a significant difference in recurrence rates (N(0) 19%, N1 20%, and N2 75%, P = .038) and DFS (N0/N1 vs. N2, 79% vs. 25%, P = .002). CONCLUSION: Neoadjuvant chemoradiation resulted in a high rate of sphincter preservation. Complete pathologic responses after surgery were frequent and although pathologic T stage after surgery did not affect recurrence rates, pathologic nodal response was associated with improved recurrence and survival rates.
Authors: Monique Maas; Patty J Nelemans; Vincenzo Valentini; Christopher H Crane; Carlo Capirci; Claus Rödel; Garrett M Nash; Li-Jen Kuo; Rob Glynne-Jones; Julio García-Aguilar; Javier Suárez; Felipe A Calvo; Salvatore Pucciarelli; Sebastiano Biondo; George Theodoropoulos; Doenja M J Lambregts; Regina G H Beets-Tan; Geerard L Beets Journal: Int J Cancer Date: 2014-12-13 Impact factor: 7.396
Authors: Rory P Kennelly; Anna Heeney; Anne White; David Fennelly; Kieran Sheahan; John M P Hyland; P Ronan O'Connell; Desmond C Winter Journal: Int J Colorectal Dis Date: 2011-12-17 Impact factor: 2.571
Authors: Yon Kuei Lim; Wai Lun Law; Rico Liu; Jensen T C Poon; Joe F M Fan; Oswens S H Lo Journal: World J Surg Oncol Date: 2010-03-26 Impact factor: 2.754