PURPOSE: To assess the relationship between lung parenchymal destruction and impaired pulmonary perfusion on a lobar level using CT and MRI in patients with emphysema. MATERIAL AND METHODS: Forty-five patients with severe emphysema (GOLD III and IV) underwent inspiratory 3D-HRCT and contrast-enhanced MR-perfusion (1.5T; 3.5mmx1.9mmx4mm). 3D-HRCT data was analyzed using a software for detection and visualization of emphysema. Emphysema was categorized in four clusters with different volumes and presented as overlay on the CT. CT and lung perfusion were visually analyzed for three lobes on each side using a four-point-score to grade the abnormalities on CT (1: predominantly small emphysema-clusters to 4: >75% large emphysema-clusters) and MRI (1: normal perfusion to 4: no perfusion). RESULTS: A total of 270 lobes were evaluated. At CT, the score was 1 for 9 lobes, 2 for 43, 3 for 77, and 4 for 141 lobes. At MRI, the score was 1 for 13 lobes, 2 for 45, 3 for 92, and 4 for 120 lobes. Matching of lung parenchymal destruction and reduced perfusion was found in 213 lobes (weighted kappa=0.8). The score was higher on CT in 44, and higher on MRI in 13 lobes. CONCLUSION: 3D-HRCT and 3D MR-perfusion show a high lobar agreement between parenchymal destruction and reduction of perfusion in patients with severe emphysema.
PURPOSE: To assess the relationship between lung parenchymal destruction and impaired pulmonary perfusion on a lobar level using CT and MRI in patients with emphysema. MATERIAL AND METHODS: Forty-five patients with severe emphysema (GOLD III and IV) underwent inspiratory 3D-HRCT and contrast-enhanced MR-perfusion (1.5T; 3.5mmx1.9mmx4mm). 3D-HRCT data was analyzed using a software for detection and visualization of emphysema. Emphysema was categorized in four clusters with different volumes and presented as overlay on the CT. CT and lung perfusion were visually analyzed for three lobes on each side using a four-point-score to grade the abnormalities on CT (1: predominantly small emphysema-clusters to 4: >75% large emphysema-clusters) and MRI (1: normal perfusion to 4: no perfusion). RESULTS: A total of 270 lobes were evaluated. At CT, the score was 1 for 9 lobes, 2 for 43, 3 for 77, and 4 for 141 lobes. At MRI, the score was 1 for 13 lobes, 2 for 45, 3 for 92, and 4 for 120 lobes. Matching of lung parenchymal destruction and reduced perfusion was found in 213 lobes (weighted kappa=0.8). The score was higher on CT in 44, and higher on MRI in 13 lobes. CONCLUSION: 3D-HRCT and 3D MR-perfusion show a high lobar agreement between parenchymal destruction and reduction of perfusion in patients with severe emphysema.
Authors: Joachim Saur; Frederik Trinkmann; Christina Doesch; Armin Scherhag; Joachim Brade; Stefan O Schoenberg; Martin Borggrefe; Jens J Kaden; Theano Papavassiliu Journal: Lung Date: 2010-07-31 Impact factor: 2.584
Authors: Mark Bryant; Sebastian Ley; Ralf Eberhardt; Ravi Menezes; Felix Herth; Oliver Sedlaczek; Hans-Ulrich Kauczor; Julia Ley-Zaporozhan Journal: Eur Radiol Date: 2014-08-28 Impact factor: 5.315
Authors: Jürgen Biederer; S Mirsadraee; M Beer; F Molinari; C Hintze; G Bauman; M Both; E J R Van Beek; J Wild; M Puderbach Journal: Insights Imaging Date: 2012-01-15
Authors: Bertram J Jobst; Mark O Wielpütz; Simon M F Triphan; Angela Anjorin; Julia Ley-Zaporozhan; Hans-Ulrich Kauczor; Jürgen Biederer; Sebastian Ley; Oliver Sedlaczek Journal: PLoS One Date: 2015-09-01 Impact factor: 3.240