OBJECTIVES: To assess how ultrasound measurements of carotid intima-media thickness (CIMT) and plaque burden compare with the Framingham Risk Score (FRS) in a clinical setting. METHODS AND RESULTS: In a cross-sectional study, we determined CIMT and plaque in 409 asymptomatic, non-diabetic hyperlipidemic subjects (242 men, age 49+/-11 years) who were assessed for risk factors and classified into FRS categories: 10-year risk < or =5% (n=191), 6-20% (n=176), and >20% (n=42). Percentiles of CIMT and plaque height and regression equations of CIMT against age obtained in 250 controls subjects were used to define atherosclerosis and estimate vascular age, respectively. There was a wide dispersion of CIMT for each FRS category. CIMT values were discordant in 242 (59%) subjects, 80% of them showing more atherosclerosis than predicted. Smoking and the metabolic syndrome explained part of the discrepancies in the intermediate-risk group. Triglycerides, homocysteine, and lipoprotein(a) did not predict atherosclerotic burden. Mean vascular age was 14.5 years older than chronological age. CONCLUSIONS: Carotid atherosclerosis findings readjust FRS categories in many asymptomatic subjects. Both carotid atherosclerotic burden and vascular age may be used to refine CHD risk and tailor preventive treatment beyond the FRS.
OBJECTIVES: To assess how ultrasound measurements of carotid intima-media thickness (CIMT) and plaque burden compare with the Framingham Risk Score (FRS) in a clinical setting. METHODS AND RESULTS: In a cross-sectional study, we determined CIMT and plaque in 409 asymptomatic, non-diabetic hyperlipidemic subjects (242 men, age 49+/-11 years) who were assessed for risk factors and classified into FRS categories: 10-year risk < or =5% (n=191), 6-20% (n=176), and >20% (n=42). Percentiles of CIMT and plaque height and regression equations of CIMT against age obtained in 250 controls subjects were used to define atherosclerosis and estimate vascular age, respectively. There was a wide dispersion of CIMT for each FRS category. CIMT values were discordant in 242 (59%) subjects, 80% of them showing more atherosclerosis than predicted. Smoking and the metabolic syndrome explained part of the discrepancies in the intermediate-risk group. Triglycerides, homocysteine, and lipoprotein(a) did not predict atherosclerotic burden. Mean vascular age was 14.5 years older than chronological age. CONCLUSIONS: Carotid atherosclerosis findings readjust FRS categories in many asymptomatic subjects. Both carotid atherosclerotic burden and vascular age may be used to refine CHD risk and tailor preventive treatment beyond the FRS.
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Authors: M Junyent; K L Tucker; J Shen; Y-C Lee; C E Smith; J Mattei; C-Q Lai; L D Parnell; J M Ordovas Journal: Nutr Metab Cardiovasc Dis Date: 2009-06-05 Impact factor: 4.222
Authors: Claudia Maria Vilas Freire; Felipe Batista Lima Barbosa; Maria Cristina C de Almeida; Paulo Augusto Carvalho Miranda; Márcia Melo Barbosa; Anelise Impeliziere Nogueira; Milena Moreira Guimarães; Maria do Carmo Pereira Nunes; Antônio Ribeiro-Oliveira Journal: Cardiovasc Diabetol Date: 2012-05-31 Impact factor: 9.951
Authors: Marcos A González-López; Marina Lacalle; Cristina Mata; María López-Escobar; Alfonso Corrales; Raquel López-Mejías; Javier Rueda; M Carmen González-Vela; Miguel A González-Gay; Ricardo Blanco; José L Hernández Journal: PLoS One Date: 2018-01-04 Impact factor: 3.240