Literature DB >> 17318383

An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function.

Atsushi Yamauchi1, Shinya Dohgu, Tsuyoshi Nishioku, Hideki Shuto, Mikihiko Naito, Takashi Tsuruo, Yasufumi Sawada, Yasufumi Kataoka.   

Abstract

1. The present study aimed at elucidating the effect of nitric oxide (NO) on blood-brain barrier (BBB) function with mouse brain capillary endothelial (MBEC4) cells.2. Histamine (20-100 microM) evoked NO production (1.6-7 microM) in MBEC4 cells in a dose-dependent manner.3. The permeability coefficient of sodium fluorescein for MBEC4 cells and the cellular accumulation of rhodamine 123 in MBEC4 cells were increased dose-dependently by the addition of NO solutions (14 and 28 microM) every 10 min during a 30-min period.4. The present study demonstrated that NO increased the permeability and inhibited the P-glycoprotein efflux pump of brain capillary endothelial cells, suggesting that NO plays an inhibitory role in the dynamic regulation of the BBB function.

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Year:  2007        PMID： 17318383     DOI： 10.1007/s10571-007-9139-z

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   4.231


  19 in total

1.  Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1).

Authors:  H Kusuhara; Y Sugiyama
Journal:  Drug Discov Today       Date:  2001-02-01       Impact factor: 7.851

2.  Functional involvement of P-glycoprotein in blood-brain barrier.

Authors:  T Tatsuta; M Naito; T Oh-hara; I Sugawara; T Tsuruo
Journal:  J Biol Chem       Date:  1992-10-05       Impact factor: 5.157

3.  Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier.

Authors:  R D Hurst; I B Fritz
Journal:  J Cell Physiol       Date:  1996-04       Impact factor: 6.384

4.  Nitric oxide donor-induced increase in permeability of the blood-brain barrier.

Authors:  W G Mayhan
Journal:  Brain Res       Date:  2000-06-02       Impact factor: 3.252

5.  Role of nitric oxide in histamine-induced increases in permeability of the blood-brain barrier.

Authors:  W G Mayhan
Journal:  Brain Res       Date:  1996-12-16       Impact factor: 3.252

6.  Intracellular and extracellular Ca2+ regulate histamine-induced release of nitric oxide in vascular endothelial cells as shown with sensitive and selective nitric oxide electrodes.

Authors:  F Kishi; Y Nakaya; A Takahashi; H Miyoshi; M Nomura; K Saito
Journal:  Pharmacol Res       Date:  1996-02       Impact factor: 7.658

7.  Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers.

Authors:  M Fontaine; W F Elmquist; D W Miller
Journal:  Life Sci       Date:  1996       Impact factor: 5.037

8.  Histamine-induced inositol phospholipid breakdown mirrors H1-receptor density in brain.

Authors:  P R Daum; C P Downes; J M Young
Journal:  Eur J Pharmacol       Date:  1983-03-04       Impact factor: 4.432

9.  Direct and continuous electrochemical measurement of noradrenaline-induced nitric oxide production in C6 glioma cells.

Authors:  S Trevin; Y Kataoka; R Kawachi; H Shuto; K Kumakura; R Oishi
Journal:  Cell Mol Neurobiol       Date:  1998-08       Impact factor: 5.046

10.  Nitric oxide donor-induced hyperpermeability of cultured intestinal epithelial monolayers: role of superoxide radical, hydroxyl radical, and peroxynitrite.

Authors:  M J Menconi; N Unno; M Smith; D E Aguirre; M P Fink
Journal:  Biochim Biophys Acta       Date:  1998-09-16
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  9 in total

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Authors:  Patrick T Ronaldson; Thomas P Davis
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Authors:  Jana Bundzikova; Zdeno Pirnik; Dora Zelena; Jens D Mikkelsen; Alexander Kiss
Journal:  Cell Mol Neurobiol       Date:  2008-09-05       Impact factor: 5.046

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Journal:  Mol Neurobiol       Date:  2017-07-20       Impact factor: 5.590

Review 4.  Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection.

Authors:  Wazir Abdullahi; Dinesh Tripathi; Patrick T Ronaldson
Journal:  Am J Physiol Cell Physiol       Date:  2018-06-27       Impact factor: 4.249

5.  YC-1, a novel potential anticancer agent, inhibit multidrug-resistant protein via cGMP-dependent pathway.

Authors:  Chin-Chuan Hung; Horng-Huei Liou
Journal:  Invest New Drugs       Date:  2010-07-31       Impact factor: 3.850

6.  Adverse effect of cyclosporin A on barrier functions of cerebral microvascular endothelial cells after hypoxia-reoxygenation damage in vitro.

Authors:  Shinya Dohgu; Tsuyoshi Nishioku; Noriko Sumi; Fuyuko Takata; Shinsuke Nakagawa; Mikihiko Naito; Takashi Tsuruo; Atsushi Yamauchi; Hideki Shuto; Yasufumi Kataoka
Journal:  Cell Mol Neurobiol       Date:  2007-10-13       Impact factor: 5.046

Review 7.  Pathophysiological impact of cigarette smoke exposure on the cerebrovascular system with a focus on the blood-brain barrier: expanding the awareness of smoking toxicity in an underappreciated area.

Authors:  Peter Mazzone; William Tierney; Mohammed Hossain; Vikram Puvenna; Damir Janigro; Luca Cucullo
Journal:  Int J Environ Res Public Health       Date:  2010-11-26       Impact factor: 3.390

Review 8.  Tobacco Use: A Major Risk Factor of Intracerebral Hemorrhage.

Authors:  Sunjoo Cho; Ashish K Rehni; Kunjan R Dave
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Review 9.  Pathobiology of tobacco smoking and neurovascular disorders: untied strings and alternative products.

Authors:  Pooja Naik; Luca Cucullo
Journal:  Fluids Barriers CNS       Date:  2015-10-31
  9 in total

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