Literature DB >> 17317954

Array painting using microdissected chromosomes to map chromosomal breakpoints.

L Backx1, H Van Esch, C Melotte, N Kosyakova, H Starke, J-P Frijns, T Liehr, J R Vermeesch.   

Abstract

Molecular characterization of breakpoints of chromosomal rearrangements is a successful strategy for the identification of candidate disease genes. Mapping translocation breakpoints and rearranged chromosomal boundaries is labor intensive and/or time consuming. Here, we present a novel and rapid procedure to map such chromosomal breakpoints by hybridizing amplified microdissection derived DNA of aberrant chromosomes to arrays containing genomic clones. We illustrate the potential of the technique by molecularly delineating the breakpoints in five small supernumerary marker chromosomes (sSMC) and mapping the breakpoints of five different chromosomal translocations. Copyright 2007 S. Karger AG, Basel.

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Substances：

Year:  2007        PMID： 17317954     DOI： 10.1159/000098181

Source DB:  PubMed          Journal:  Cytogenet Genome Res        ISSN： 1424-8581            Impact factor:   1.636


  12 in total

1.  Breakpoint analysis of balanced chromosome rearrangements by next-generation paired-end sequencing.

Authors:  Wei Chen; Reinhard Ullmann; Claudia Langnick; Corinna Menzel; Zofia Wotschofsky; Hao Hu; Andreas Döring; Yuhui Hu; Hui Kang; Andreas Tzschach; Maria Hoeltzenbein; Heidemarie Neitzel; Susanne Markus; Eberhard Wiedersberg; Gerd Kistner; Conny M A van Ravenswaaij-Arts; Tjitske Kleefstra; Vera M Kalscheuer; Hans-Hilger Ropers
Journal:  Eur J Hum Genet       Date:  2009-12-02       Impact factor: 4.246

Review 2.  Chromosome 5 derived small supernumerary marker: towards a genotype/phenotype correlation of proximal chromosome 5 imbalances.

Authors:  Joana Barbosa Melo; Liesbeth Backx; Joris R Vermeesch; Heloisa G Santos; Ana C Sousa; Nadezda Kosyakova; Anja Weise; Ferdinand von Eggeling; Thomas Liehr; Isabel Marques Carreira
Journal:  J Appl Genet       Date:  2011-03-25       Impact factor: 3.240

3.  FAF1, a gene that is disrupted in cleft palate and has conserved function in zebrafish.

Authors:  Michella Ghassibe-Sabbagh; Laurence Desmyter; Tobias Langenberg; Filip Claes; Odile Boute; Bénédicte Bayet; Philippe Pellerin; Karlien Hermans; Liesbeth Backx; Maria Adela Mansilla; Sandra Imoehl; Stefanie Nowak; Kerstin U Ludwig; Carlotta Baluardo; Melissa Ferrian; Peter A Mossey; Markus Noethen; Mieke Dewerchin; Geneviève François; Nicole Revencu; Romain Vanwijck; Jacqueline Hecht; Elisabeth Mangold; Jeffrey Murray; Michele Rubini; Joris R Vermeesch; Hélène A Poirel; Peter Carmeliet; Miikka Vikkula
Journal:  Am J Hum Genet       Date:  2011-02-03       Impact factor: 11.025

4.  Supernumerary marker chromosomes derived from chromosome 6: cytogenetic, molecular cytogenetic, and array CGH characterization.

Authors:  Bing Huang; Phyllis Pearle; Katherine A Rauen; Philip D Cotter
Journal:  Am J Med Genet A       Date:  2012-05-25       Impact factor: 2.802

5.  Array painting: a protocol for the rapid analysis of aberrant chromosomes using DNA microarrays.

Authors:  Susan M Gribble; Bee Ling Ng; Elena Prigmore; Tomas Fitzgerald; Nigel P Carter
Journal:  Nat Protoc       Date:  2009-11-05       Impact factor: 13.491

6.  Mapping translocation breakpoints by next-generation sequencing.

Authors:  Wei Chen; Vera Kalscheuer; Andreas Tzschach; Corinna Menzel; Reinhard Ullmann; Marcel Holger Schulz; Fikret Erdogan; Na Li; Zofia Kijas; Ger Arkesteijn; Isidora Lopez Pajares; Margret Goetz-Sothmann; Uwe Heinrich; Imma Rost; Andreas Dufke; Ute Grasshoff; Birgitta Glaeser; Martin Vingron; H Hilger Ropers
Journal:  Genome Res       Date:  2008-03-07       Impact factor: 9.043

Review 7.  Characterising chromosome rearrangements: recent technical advances in molecular cytogenetics.

Authors:  S Le Scouarnec; S M Gribble
Journal:  Heredity (Edinb)       Date:  2011-11-16       Impact factor: 3.821

8.  Clinical impact of proximal autosomal imbalances.

Authors:  Ab Hamid; A Weise; M Voigt; M Bucksch; N Kosyakova; T Liehr; E Klein
Journal:  Balkan J Med Genet       Date:  2012-12       Impact factor: 0.519

9.  A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis.

Authors:  R Thomas; S E Duke; E K Karlsson; A Evans; P Ellis; K Lindblad-Toh; C F Langford; M Breen
Journal:  Cytogenet Genome Res       Date:  2008-12-18       Impact factor: 1.636

10.  Complex rearranged small supernumerary marker chromosomes (sSMC), three new cases; evidence for an underestimated entity?

Authors:  Vladimir Trifonov; Simon Fluri; Franz Binkert; Adayapalam Nandini; Jasen Anderson; Laura Rodriguez; Madeleine Gross; Nadezda Kosyakova; Hasmik Mkrtchyan; Elisabeth Ewers; Daniela Reich; Anja Weise; Thomas Liehr
Journal:  Mol Cytogenet       Date:  2008-04-15       Impact factor: 2.009
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